Neutrophils activated by micropatches hold promising prospects in tumor immunotherapy

Mengran Chen, Bingyang Chu, Yu Wu
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Abstract

This study used polymer micropatches as a platform for sustained and targeted activation of neutrophils. The micropatches can promote the rapid conversion of neutrophils to the N1 type while also enhancing the activation of other immune cells in vivo. The activated neutrophils are recruited to the tumor site, where they exert effective antitumor effects.

Abstract Image

微补丁激活的中性粒细胞在肿瘤免疫疗法中大有可为
这项研究利用聚合物微补丁作为持续和定向激活中性粒细胞的平台。微补丁能促进中性粒细胞快速转化为 N1 型,同时还能增强体内其他免疫细胞的活化。活化的中性粒细胞被招募到肿瘤部位,并在那里发挥有效的抗肿瘤作用。
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