{"title":"Complexation of Gold(I) and Gold(III) in solutions","authors":"","doi":"10.1016/j.ccr.2024.216162","DOIUrl":null,"url":null,"abstract":"<div><p>The present review critically observes literature data on stability constants of gold(I) and gold(III) complexes in aqueous and non-aqueous medium. The equilibrium constants of complexation or ligand exchange as well as the values of E<sup>0</sup> for the redox processes [Au<sup>+3</sup>L<sub>x</sub>]<sup>z±</sup> + 3e = Au + xL<sup>(−3±z)/x</sup> and [Au<sup>+1</sup>L<sub>x</sub>]<sup>z±</sup> + e = Au + xL<sup>(−1±z)/x</sup> are reported or calculated using the results of other researchers. Information about the composition and stability of the products formed by gold species with macrobiomolecules such as proteins and DNA is provided. When analyzing an interaction between a gold complex and biomolecule, several competing processes should be taken into account, including equilibria of ligand exchange, hydrolysis of gold complex, and binding of gold or free ligand to protein or DNA. The review aims to help those who develop new gold-based drugs and might be of interest to specialists in gold chemistry.</p></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":null,"pages":null},"PeriodicalIF":20.3000,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010854524005083","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
The present review critically observes literature data on stability constants of gold(I) and gold(III) complexes in aqueous and non-aqueous medium. The equilibrium constants of complexation or ligand exchange as well as the values of E0 for the redox processes [Au+3Lx]z± + 3e = Au + xL(−3±z)/x and [Au+1Lx]z± + e = Au + xL(−1±z)/x are reported or calculated using the results of other researchers. Information about the composition and stability of the products formed by gold species with macrobiomolecules such as proteins and DNA is provided. When analyzing an interaction between a gold complex and biomolecule, several competing processes should be taken into account, including equilibria of ligand exchange, hydrolysis of gold complex, and binding of gold or free ligand to protein or DNA. The review aims to help those who develop new gold-based drugs and might be of interest to specialists in gold chemistry.
本综述对有关金（I）和金（III）配合物在水介质和非水介质中稳定性常数的文献数据进行了严格的观察。报告了络合或配体交换的平衡常数，以及氧化还原过程 [Au+3Lx]z± + 3e = Au + xL(-3±z)/x 和 [Au+1Lx]z± + e = Au + xL(-1±z)/x 的 E0 值，或利用其他研究人员的结果进行了计算。报告还提供了有关金与蛋白质和 DNA 等大生物大分子形成的产物的组成和稳定性的信息。在分析金络合物与生物大分子之间的相互作用时，应考虑到几个竞争过程，包括配体交换平衡、金络合物水解以及金或游离配体与蛋白质或 DNA 的结合。这篇综述旨在帮助开发新的金基药物，金化学专家可能也会感兴趣。
期刊介绍：
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.
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