Microencapsulated sardine Oil using vanillic acid grafted chitosan as wall material: Alleviating effect on streptozotocin-induced hyperglycemia in rats
{"title":"Microencapsulated sardine Oil using vanillic acid grafted chitosan as wall material: Alleviating effect on streptozotocin-induced hyperglycemia in rats","authors":"Vishnu Kalladathvalappil Venugopalan , Ajeeshkumar Kizhakkeppurath Kumaran , Ruby Varghese , Yogesh Bharat Dalvi , Sootawat Benjakul , Suseela Mathew , Ammanamveetil Abdulla Mohamed Hatha , Niladri Sekhar Chatterjee","doi":"10.1016/j.prenap.2024.100076","DOIUrl":null,"url":null,"abstract":"<div><p>Impact of an innovative antioxidant wall material, vanillic acid-grafted chitosan, on enhancement of oxidative stability was investigated. Microencapsulation with the aid of spray drying was proven to be an effective method for preserving omega-3 fatty acids. Streptozotocin-induced diabetic rats were used to examine the effects of microcapsules loaded with sardine oil and vanillic acid-grafted chitosan (SO-MC) as wall material. Antioxidant and anti-hyperglycemic effects were significantly enhanced in rat models treated with 500 mg/kg of SO-MC. The lack of aberrant weight fluctuations or mortality in an acute toxicity assessment indicated that there were no symptoms of toxicity. Addition of SO-MC into the meal resulted in dose-dependent decreases in blood glucose levels as compared to the diabetes control group. Treatment with SO-MC reduced lipid peroxidation, whereas increased production of glutathione peroxidase (GPx) and glutathione S-transferase (GSH), two crucial antioxidants, as compared to the diabetes control group. These findings underscore the potential utility of SO-MC as a promising dietary supplement for the management of hyperglycemia</p></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"4 ","pages":"Article 100076"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199724000648","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Impact of an innovative antioxidant wall material, vanillic acid-grafted chitosan, on enhancement of oxidative stability was investigated. Microencapsulation with the aid of spray drying was proven to be an effective method for preserving omega-3 fatty acids. Streptozotocin-induced diabetic rats were used to examine the effects of microcapsules loaded with sardine oil and vanillic acid-grafted chitosan (SO-MC) as wall material. Antioxidant and anti-hyperglycemic effects were significantly enhanced in rat models treated with 500 mg/kg of SO-MC. The lack of aberrant weight fluctuations or mortality in an acute toxicity assessment indicated that there were no symptoms of toxicity. Addition of SO-MC into the meal resulted in dose-dependent decreases in blood glucose levels as compared to the diabetes control group. Treatment with SO-MC reduced lipid peroxidation, whereas increased production of glutathione peroxidase (GPx) and glutathione S-transferase (GSH), two crucial antioxidants, as compared to the diabetes control group. These findings underscore the potential utility of SO-MC as a promising dietary supplement for the management of hyperglycemia
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
