The relationship between lung cancer and hepatosteatosis in patients with biopsy-confirmed lung cancer diagnosis.

Northern clinics of Istanbul Pub Date : 2024-08-02 eCollection Date: 2024-01-01 DOI:10.14744/nci.2024.88972
Murat Asik, Mehmet Ali Agirbasli, Kendal Erincik
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Abstract

Objective: The purpose of this study is to evaluate whether hepatosteatosis is associated with lung cancer in patients undergoing lung nodule biopsy.

Methods: 359 patients (248 males, 69.1%) who underwent lung biopsy between the years 2016 and 2022 were included in this retrospective study. The average age of the patients was 64.59±14.05 (range=30-90) years. These patients were undergoing follow-up for a lung lesion and had undergone thoraco-abdominal CT scans. Attenuation measurements were performed on non-contrast CT scans from the liver and spleen parenchyma.

Results: Pathology results showed that the majority of diagnoses were malignant (n=265, 73.8%). Statistical analysis revealed a significantly higher number of patients with malignancy among those with hepatosteatosis compared to those without hepatosteatosis (73% vs. 57%, p=0.006). Furthermore, patients with malignancy were more frequently male (73 vs. 27%, p=0.010), older (65.80±12.83 years vs. 61.20±16.63 years; p=0.06) and had a higher prevalence of diabetes mellitus (DM) (43.7 vs. 31.9%, p=0.046). Logistic regression analysis indicated that advanced age, DM, and hepatosteatosis were associated with an increased risk of malignancy (p=0.049, 95% CI (1.000-1.036), p=0.044, 95% CI (0.0347-0.98736), p=0.013, 95% CI (1.154-3.323), respectively).

Conclusion: The study findings suggest that hepatosteatosis might be associated with lung cancer. Therefore, due to its possible relationship with lung cancer, it should be taken very seriously, considering the chance of early diagnosis and treatment.

经活检确诊为肺癌的患者中肺癌与肝病之间的关系。
研究目的本研究旨在评估接受肺结节活检的患者中,肝脂肪变性是否与肺癌有关。方法:本回顾性研究纳入了在 2016 年至 2022 年期间接受肺活检的 359 例患者(男性 248 例,占 69.1%)。患者的平均年龄为(64.59±14.05)岁(范围=30-90)岁。这些患者正在接受肺部病变的随访,并接受了胸腹CT扫描。对肝脏和脾脏实质的非对比 CT 扫描进行了衰减测量:病理结果显示,大多数诊断结果为恶性(n=265,73.8%)。统计分析显示,与非肝硬变患者相比,肝硬变患者中的恶性肿瘤患者人数明显较多(73% 对 57%,P=0.006)。此外,恶性肿瘤患者多为男性(73% 对 27%,P=0.010),年龄更大(65.80±12.83 岁对 61.20±16.63岁,P=0.06),糖尿病(DM)患病率更高(43.7% 对 31.9%,P=0.046)。逻辑回归分析表明,高龄、DM 和肝软化症与恶性肿瘤风险增加相关(分别为 p=0.049,95% CI (1.000-1.036);p=0.044,95% CI (0.0347-0.98736);p=0.013,95% CI (1.154-3.323)):研究结果表明,肝脂肪变性可能与肺癌有关。结论:研究结果表明,肝细胞脂肪变性可能与肺癌有关,因此,考虑到肝细胞脂肪变性与肺癌的可能关系,应高度重视肝细胞脂肪变性,以获得早期诊断和治疗的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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