Measurable residual disease (MRD)-testing in haematological cancers: A giant leap forward or sideways?

IF 6.9 2区 医学 Q1 HEMATOLOGY
Qiujin Shen, Xiaowen Gong, Yahui Feng, Yu Hu, Tiantian Wang, Wen Yan, Wei Zhang, Saibing Qi, Robert Peter Gale, Junren Chen
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引用次数: 0

Abstract

Measurable residual disease (MRD)-testing is used in many haematological cancers to estimate relapse risk and to direct therapy. Sometimes MRD-test results are used for regulatory approval. However, some people including regulators wrongfully believe results of MRD-testing are highly accurate and of proven efficacy in directing therapy. We review MRD-testing technologies and evaluate the accuracy of MRD-testing for predicting relapse and the strength of evidence supporting efficacy of MRD-guided therapy. We show that at the individual level MRD-test results are often an inaccurate relapse predictor. Also, no convincing data indicate that increasing therapy-intensity based on a positive MRD-test reduces relapse risk or improves survival. We caution against adjusting therapy-intensity based solely on results of MRD-testing.

血液肿瘤中的可测量残留疾病(MRD)检测:大跃进还是走弯路?
可测量残留病(MRD)检测用于许多血液癌症,以估计复发风险并指导治疗。有时,MRD 检测结果会被用于监管审批。然而,包括监管机构在内的一些人错误地认为 MRD 检测的结果非常准确,而且在指导治疗方面具有公认的疗效。我们回顾了 MRD 检测技术,并评估了 MRD 检测在预测复发方面的准确性以及支持 MRD 指导疗法疗效的证据力度。我们发现,就个体而言,MRD 检测结果往往不能准确预测复发。此外,没有令人信服的数据表明,根据MRD检测阳性结果增加治疗强度可降低复发风险或提高生存率。我们提醒不要仅根据 MRD 检测结果来调整治疗强度。
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来源期刊
Blood Reviews
Blood Reviews 医学-血液学
CiteScore
13.80
自引率
1.40%
发文量
78
期刊介绍: Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.
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