Prognostic impact of abdominal aortic calcification in patients who underwent hepatectomy for intrahepatic cholangiocarcinoma.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2025-04-01 Epub Date: 2024-08-20 DOI:10.1007/s00595-024-02922-x

Yuto Yamahata, Takeshi Gocho, Kenei Furukawa, Koichiro Haruki, Shinji Onda, Yoshihiro Shirai, Masashi Tsunematsu, Tomohiko Taniai, Mitsuru Yanagaki, Michinori Matsumoto, Ryoga Hamura, Norimitsu Okui, Yoshiaki Tanji, Toru Ikegami

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引用次数: 0

Abstract

Purpose: Abdominal aortic calcification (AAC), an indicator of systemic arteriosclerosis, is associated with short- and long-term outcomes in malignancies. We investigated the prognostic impact of AAC in patients who underwent hepatectomy for intrahepatic cholangiocarcinoma (IHCC).

Methods: The study cohort comprised 46 patients who underwent hepatectomy for IHCC between January 2008 and September 2020. The AAC volume measured by preoperative computed tomography was used to construct a model of the calcified segment from the renal artery to the common iliac artery bifurcation. We investigated the relationship between AAC and the long-term outcomes. The AAC volume cutoff value was calculated from a receiver-operating characteristic curve based on the three-year survival.

Results: According to our cutoff AAC volume of 3,700 mm³, 11 patients (24%) had high AAC volumes. The high-AAC group was significantly older than the low-AAC group (73 vs. 62 years old, p < 0.01). A multivariate analysis of the cancer-specific survival showed that a high serum carbohydrate antigen 19-9 concentration (hazard ratio [HR] 5.57, p = 0.01), high AAC volume (HR 3.03, p = 0.04), and [high?] T3 or T4 levels (HR 9.05, p < 0.01) were independently associated with a poor prognosis.

Conclusion: AAC is a useful predictor of the oncological prognosis in patients undergoing hepatectomy for IHCC.

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肝内胆管癌肝切除术患者腹主动脉钙化的预后影响

目的：腹主动脉钙化（AAC）是全身动脉硬化的一个指标，与恶性肿瘤的短期和长期预后有关。我们研究了腹主动脉钙化对肝内胆管癌（IHCC）肝切除术患者预后的影响：研究队列包括2008年1月至2020年9月期间因IHCC接受肝切除术的46例患者。术前计算机断层扫描测量的AAC体积被用于构建从肾动脉到髂总动脉分叉处的钙化段模型。我们研究了AAC与长期预后之间的关系。根据三年存活率的接收者操作特征曲线计算出了AAC体积的临界值：根据我们的 AAC 截断值 3,700 mm3，11 名患者（24%）的 AAC 容量较大。高AAC组患者的年龄明显高于低AAC组（73岁对62岁，P 结论：AAC是预测癌症的有效指标：AAC是预测IHCC肝切除术患者肿瘤预后的有效指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.