Clinical significance of sarcopenia in children with neuroblastic tumors.

IF 1.5 3区医学 Q2 PEDIATRICS

Pediatric Surgery International Pub Date : 2024-08-21 DOI:10.1007/s00383-024-05815-9

Wataru Kudo, Keita Terui, Ryoya Furugane, Ayako Takenouchi, Shugo Komatsu, Yunosuke Kawaguchi, Katsuhiro Nishimura, Daisuke Katsumi, Tomoro Hishiki

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引用次数: 0

Abstract

Purpose: To elucidate the clinical significance of sarcopenia in children with neuroblastic tumors (NTs).

Methods: We conducted a retrospective observational study and analyzed the z-scores for height, body weight, body mass index, and skeletal muscle index (HT-z, BW-z, BMI-z, and SMI-z) along with the clinical characteristics of 36 children with NTs. SMI-z was calculated from 138 computed tomography scans at diagnosis, during treatment, and at follow-up. The International Neuroblastoma Risk Group classification was used to identify high-risk groups. We analyzed the data at diagnosis for prognostic analysis and changes over time after diagnosis in the HT-z, BW-z, BMI-z, and SMI-z groups.

Results: Among the four parameters at diagnosis, only SMI-z predicted overall survival (hazard ratio, 0.58; 95% confidence interval, 0.34-0.99). SMI-z, HT-z, and BW-z significantly decreased over time after diagnosis (P < 0.05), while BMI-z did not (P = 0.11). In surviving high-risk NT cases without disease, SMI-z, HT-z, and BW-z significantly decreased over time (P < 0.05), while BMI-z did not (P = 0.43).

Conclusion: In children with NT, the SMI-z at diagnosis was a significant prognostic factor and decreased during treatment and follow-up along with HT-z and BW-z. Monitoring muscle mass is important because sarcopenia may be associated with growth impairment.

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神经母细胞瘤患儿肌少症的临床意义。

目的：阐明神经母细胞瘤（NTs）患儿肌肉疏松症的临床意义：我们进行了一项回顾性观察研究，分析了 36 名 NTs 患儿的身高、体重、体重指数和骨骼肌指数 z 值（HT-z、BW-z、BMI-z 和 SMI-z）以及临床特征。SMI-z是根据诊断时、治疗期间和随访时的138次计算机断层扫描结果计算得出的。国际神经母细胞瘤风险组分类用于识别高风险组。我们对诊断时的数据进行了预后分析，并分析了HT-z组、BW-z组、BMI-z组和SMI-z组诊断后随时间的变化：在诊断时的四个参数中，只有 SMI-z 能预测总生存期（危险比为 0.58；95% 置信区间为 0.34-0.99）。SMI-z、HT-z和BW-z在确诊后随时间推移显著下降（P在 NT 患儿中，确诊时的 SMI-z 是一个重要的预后因素，并且在治疗和随访期间与 HT-z 和 BW-z 一起下降。监测肌肉质量非常重要，因为肌少症可能与生长障碍有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Surgery International 医学-外科

CiteScore

3.00

自引率

5.60%

发文量

215

审稿时长

3-6 weeks

期刊介绍： Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children. The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include: -Review articles- Original articles- Technical innovations- Letters to the editor