Serum neurofilament light at diagnosis: a prognostic indicator for accelerated disease progression in Parkinson's Disease.

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2024-08-21 DOI:10.1038/s41531-024-00768-1

Camilla Christina Pedersen, Anastasia Ushakova, Guido Alves, Ole-Bjørn Tysnes, Kaj Blennow, Henrik Zetterberg, Jodi Maple-Grødem, Johannes Lange

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Abstract

Neurofilament light chain (NFL) is elevated in neurodegenerative diseases, including Parkinson's disease (PD). This study aimed to investigate serum NFL in newly diagnosed PD and its association with cognitive and motor decline over 10 years. Serum NFL levels were measured in PD patients and controls from the ParkWest study at diagnosis (baseline) and after 3 and 5 years. Mixed-effects regression analyzed changes in NFL and the association with annual changes in MMSE and UPDRS-III scores over 10 years. PD patients had elevated serum NFL at all visits and a faster annual increase over 5 years compared to controls (0.09 pg/mL per year; p = 0.029). Higher baseline NFL predicted faster cognitive decline β -0.77 transformed MMSE; p = 0.010), and a 40% NFL increase predicted future motor decline (β 0.28 UPDRS-III; p = 0.004). Elevated serum NFL in early PD is linked to faster cognitive and motor impairment, suggesting its prognostic value in PD biomarker panels.

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诊断时的血清神经丝光：帕金森病疾病进展加速的预后指标。

神经丝蛋白轻链（NFL）在包括帕金森病（PD）在内的神经退行性疾病中会升高。本研究旨在调查新诊断帕金森病患者的血清 NFL 及其与 10 年认知和运动功能衰退的关系。在诊断时（基线）以及 3 年和 5 年后，对 ParkWest 研究中的帕金森病患者和对照组进行了血清 NFL 水平测定。混合效应回归分析了 NFL 的变化以及与 10 年间 MMSE 和 UPDRS-III 评分的年度变化之间的关系。与对照组相比，帕金森病患者在所有就诊时血清 NFL 均升高，且 5 年内的年增长率更快（每年 0.09 pg/mL；p = 0.029）。较高的基线 NFL 预测认知能力下降较快 β -0.77 转化 MMSE；p = 0.010），NFL 增加 40% 预测未来运动能力下降（β 0.28 UPDRS-III；p = 0.004）。早期帕金森病患者血清NFL升高与认知和运动功能受损速度加快有关，这表明NFL在帕金森病生物标志物组中具有预后价值。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.