Electrostatically self-assembled gold nanorods with sulfated hyaluronic acid for targeted photothermal therapy for CD44-positive tumors

IF 4.2 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-08-18 DOI:10.1016/j.nano.2024.102781

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Abstract

Gold nanorods (GNR) produce heat upon irradiation with near-infrared light, enabling a tumor-targeted photothermal therapy. In this study, we prepared GNR coated with sulfated hyaluronic acid (sHA) with a binding affinity for CD44 via electrostatic interactions to deliver GNR to tumors efficiently and stably, and evaluated their usefulness for photothermal therapy. Cationic GNR modified with trimethylammonium groups electrostatically interacted with native HA or sHA with varying degrees of sulfation to form complexes. While GNR/HA was unstable in saline, GNR/sHA maintained the absorbance peak in the near-infrared region, particularly for GNR/sHA with higher degrees of sulfation. GNR/sHA exhibited an intense photothermal effect upon irradiation with near-infrared light. Furthermore, in vitro and in vivo studies revealed that GNR coated with sHA containing approximately 1.2 sulfated groups per HA unit could accumulate in CD44-positive tumors via an HA-specific pathway. These findings indicate the effectiveness of GNR/sHA as a tumor-targeted photothermal therapeutic agent.

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含硫酸化透明质酸的静电自组装金纳米棒用于 CD44 阳性肿瘤的靶向光热疗法。

金纳米棒（GNRs）在近红外线照射下会产生热量，从而实现肿瘤靶向光热疗法。在这项研究中，我们制备了涂有硫酸化透明质酸（sHA）的 GNRs，通过静电相互作用与 CD44 产生结合亲和力，从而将 GNRs 高效、稳定地输送到肿瘤中，并评估了它们在光热疗法中的作用。用三甲基铵基团修饰的阳离子 GNR 与原生 HA 或不同硫酸化程度的 sHA 发生静电相互作用，形成复合物。GNR/HA 在生理盐水中不稳定，而 GNR/sHA 则在近红外区域保持吸光峰，特别是硫酸化程度较高的 GNR/sHA。在近红外线照射下，GNR/sHA 表现出强烈的光热效应。此外，体外和体内研究表明，涂有每 HA 单位含有约 1.2 个硫酸化基团的 sHA 的 GNR 可通过 HA 特异性途径在 CD44 阳性肿瘤中聚集。这些研究结果表明，GNR/SHA 是一种有效的肿瘤靶向光热治疗剂。

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来源期刊

Nanomedicine : nanotechnology, biology, and medicine 工程技术-纳米科技

CiteScore

11.10

自引率

0.00%

发文量

133

审稿时长

42 days

期刊介绍： The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.