Comparing visualization performance of liquid embolic agents using a novel injectable phantom.

IF 1.7 4区医学 Q3 Medicine

Interventional Neuroradiology Pub Date : 2024-08-21 DOI:10.1177/15910199241276581

J Ryan Mason, Cristina Dodge, Adam Beardsley, Susan Hilsenbeck, Goetz Benndorf

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引用次数: 0

Abstract

Background: Radiographic visualization of liquid embolic agents (LEAs) during embolization procedures in neurovascular territory represents a crucial feature to ensure efficacy and safety for the patients during endovascular treatment of arteriovenous shunting lesions. Radiopacity of available LEAs varies significantly and limited methods are currently available for comparison. The purpose of this study was to compare the contrast resolution (CR) during injection under blank roadmap of various LEAs, as well as standard contrast material.

Methods: An injectable angiographic phantom was designed consisting of parallel tubings between 313 and 1000 micron. Under roadmap, eight radiopaque liquid agents were injected and analyzed: Onyx18^®, 34^® Squid^®12, 18, PHIL^®25% (PHIL^®25), PHIL^®30% (PHIL^®30).Trufill^TM (NBCA), 30% dilution and Omnipaque^®300. CR was evaluated as a contrast to noise ratio (CNR) and calculated as mean peak signal (Sa) minus mean background signal (Sb) divided by the standard deviation of the background signal (Std) $(C N R = \frac{S a - S b}{S t d})$ .

Results: Omnipaque 300 and NBCA were found to have the highest CR. PHIL^®25 demonstrated the lowest CNR (45% of Omnipaque CNR). Onyx 18 and 34 (Both around 82% of Omnipaque CNR) demonstrated higher CNR compared to Squid^®12 and 18 (52-55% of Omnipaque CNR). On average, at 500 micron there is a >70% reduction in CNR, and at 313 micron there is a 90% reduction in CNR compared to 1000 micron.

Conclusions: Significantly different CNR between most LEAs and iodinated contrast media was evident under roadmap conditions and should be considered prior to injection.

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使用新型注射模型比较液体栓塞剂的可视化性能。

背景：在神经血管区域进行栓塞手术时，液态栓塞剂（LEAs）的射线可视化是确保动静脉分流病变血管内治疗疗效和患者安全的关键特征。现有 LEA 的放射能力差异很大，目前可供比较的方法有限。本研究的目的是比较各种 LEA 和标准造影剂在空白路标下注射时的造影剂分辨率（CR）：方法：设计了一个可注射的血管造影模型，由 313 微米到 1000 微米的平行管组成。方法：设计了一个由 313 微米和 1000 微米之间的平行管组成的可注射血管造影模型，在路标下注射并分析了八种不透射线的液体制剂：Onyx18®、34® Squid®12、18、PHIL®25% (PHIL®25)、PHIL®30% (PHIL®30)、TrufillTM (NBCA)、30% 稀释和 Omnipaque®300。CR以对比度与噪声比（CNR）进行评估，计算公式为平均峰值信号（Sa）减去平均背景信号（Sb）再除以背景信号的标准偏差（std）（CNR=Sa-SbStd）：结果发现，Omnipaque 300 和 NBCA 的 CR 值最高。PHIL®25 的 CNR 最低（为 Omnipaque CNR 的 45%）。与 Squid®12 和 18（Omnipaque CNR 的 52-55%）相比，Onyx 18 和 34（均约为 Omnipaque CNR 的 82%）具有更高的 CNR。平均而言，与 1000 微米相比，500 微米的 CNR 降低了 70%，313 微米的 CNR 降低了 90%：在路标条件下，大多数 LEA 和碘化造影剂的 CNR 明显不同，注射前应加以考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Interventional Neuroradiology 医学-核医学

CiteScore

2.80

自引率

11.80%

发文量

192

审稿时长

6-12 weeks

期刊介绍： Interventional Neuroradiology (INR) is a peer-reviewed clinical practice journal documenting the current state of interventional neuroradiology worldwide. INR publishes original clinical observations, descriptions of new techniques or procedures, case reports, and articles on the ethical and social aspects of related health care. Original research published in INR is related to the practice of interventional neuroradiology...