An emerging epidemic of allergic contact dermatitis due to phytonadione epoxide (oxidised vitamin K1)

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2024-08-20 DOI:10.1111/cod.14675

María E. Gatica-Ortega, María A. Pastor-Nieto, Ana María Giménez-Arnau, Pedro Mercader-García, Esther Serra-Baldrich, Violeta Zaragoza-Ninet, Tatiana Sanz-Sánchez, Araceli Sánchez-Gilo, David Pesqué, Fátima Tous-Romero, Francisco Javier Ortiz-de-Frutos, Eduardo de la Rosa-Fernández, Sara Dorta-Alom, Marta Elosua-González, Ricardo González-Pérez, José Manuel Carrascosa-Carrillo, Mónica Munera-Campos, Juan Francisco Silvestre-Salvador, Javier Miquel-Miquel, Antonio de Mateo Minguez, Leopoldo Borrego

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Abstract

Background

Reports of allergic contact dermatitis (ACD) to phytonadione epoxide (PE) in cosmetics suggest that PE is as powerful a sensitiser as its parent compound phytonadione.

Objective

To evaluate a case series of ACD to PE in Spain.

Methods

We reviewed the records of 20 patients with ACD to cosmetics containing PE diagnosed across Spain between January 2019 and June 2023.

Results

All 20 patients developed patch test (PT) or repeated open application test (ROAT) reactions to cosmetics containing PE. All involved women with eyelid eczema. PT or ROAT with PE preparations were positive in 17/20 (85%). PE at 1%, 5%, 10% and 20% in pet. was patch-tested in 8/17, 14/17, 11/17 and 8/17 patients; being positive in 6/8 (75%), 13/14 (92.85%), 11/11 (100%) and 8/8 (100%), respectively.

Conclusion

Regulators should, not only ban the specific dangerous cosmetic ingredients, but also consider to ban or keep under close surveillance those closely related products or derivatives that might potentially cause similar harmful effects. PTs with PE are suggested to be performed at a 5% concentration in pet. Higher concentrations (10% pet.) should be tested whenever PTs with 5% pet. PE are negative.

Abstract Image

查看原文本刊更多论文

一种新出现的由环氧化芬多精（氧化维生素 K1）引起的过敏性接触性皮炎流行病。

背景：有关化妆品中的环氧辛二酮（PE）引起过敏性接触性皮炎（ACD）的报道表明，PE与其母体化合物辛二酮一样具有很强的致敏性：评估西班牙 PE 引起的 ACD 病例系列：方法：我们回顾了 2019 年 1 月至 2023 年 6 月期间在西班牙各地确诊的 20 例含有 PE 的化妆品过敏性休克患者的病历：所有20名患者均对含有PE的化妆品产生了斑贴试验（PT）或重复开放涂抹试验（ROAT）反应。所有患者均为患有眼睑湿疹的女性。17/20（85%）的患者对 PE 制剂的贴片试验或 ROAT 呈阳性反应。对8/17、14/17、11/17和8/17名患者分别进行了PE含量为1%、5%、10%和20%的贴敷试验，结果分别有6/8（75%）、13/14（92.85%）、11/11（100%）和8/8（100%）人呈阳性反应：监管机构不仅应禁用特定的危险化妆品成分，还应考虑禁用或密切监视那些可能造成类似有害影响的密切相关产品或衍生物。建议在宠物体内进行 5%浓度的 PE 试验。如果用 5%的宠物 PE 进行 PT 检测呈阴性，则应检测更高浓度（10%）的 PE。PE 的 PT 呈阴性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".