A Comprehensive Compilation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Neonatal Respiratory Distress Syndrome.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2024-09-01 Epub Date: 2024-08-19 DOI:10.1080/15513815.2024.2390932

Mohammad Golshan-Tafti, Reza Bahrami, Seyed Alireza Dastgheib, Mohamad Hosein Lookzadeh, Seyed Reza Mirjalili, Maryam Yeganegi, Zahra Marzbanrad, Maryam Aghasipour, Amirhossein Shahbazi, Ali Masoudi, Mahmood Noorishadkam, Hossein Neamatzadeh

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引用次数: 0

Abstract

Background: This study aims to explore the association between variations in the Surfactant Protein-B (SFTPB) gene and the risk of neonatal respiratory distress syndrome (NRDS).

Methods: A comprehensive literature search was conducted across PubMed, Scopus, EMBASE, and CNKI databases up to February 10, 2024, to identify pertinent studies.

Results: A total of seventeen studies examining the +1580 C/T polymorphism (2,058 cases and 2,596 controls) and five studies investigating the -18 A/C polymorphism (680 cases and 739 controls) were included in the analysis. The pooled data indicated that the +1580 C/T polymorphism confers a protective effect against NRDS in various populations and ethnic groups. Conversely, the -18 A/C polymorphism did not demonstrate a significant association either globally or among Asian neonates.

Conclusions: The +1580 C/T variant appears to be protective against NRDS, whereas the -18 A/C polymorphism shows minimal impact on the disease's progression.

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关于表面活性蛋白-B (SFTPB) 多态性与新生儿呼吸窘迫综合征易感性之间关系的数据综合汇编。

背景：本研究旨在探讨表面活性蛋白-B（SFTPB）基因变异与新生儿呼吸窘迫综合征（NRDS）风险之间的关联：本研究旨在探讨表面活性蛋白-B（SFTPB）基因变异与新生儿呼吸窘迫综合征（NRDS）风险之间的关联：方法：对截至2024年2月10日的PubMed、Scopus、EMBASE和CNKI数据库进行了全面的文献检索，以确定相关研究：共有 17 项研究（2058 例病例和 2596 例对照）检测了 +1580 C/T 多态性，5 项研究（680 例病例和 739 例对照）检测了 -18 A/C 多态性。汇总数据显示，在不同人群和族群中，+1580 C/T 多态性对 NRDS 具有保护作用。相反，-18 A/C多态性在全球和亚洲新生儿中均未显示出显著的相关性：结论：+1580 C/T变异似乎对NRDS有保护作用，而-18/Ac多态性对疾病进展的影响微乎其微。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.