Clinical presentation and magnetic resonance imaging findings of a spinal cord ganglioglioma in a 7.5-year-old, male, neutered German shepherd dog.

IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES
Veterinary Radiology & Ultrasound Pub Date : 2024-11-01 Epub Date: 2024-08-19 DOI:10.1111/vru.13426
Emily K Swan, Richard T Brooksby, Robert Jones, Iren Horkayne-Szakaly, Jey Koehler, Elise E B LaDouceur
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引用次数: 0

Abstract

A dog presented with a 1-month history of left-sided hemiparesis. MRI showed a focal, 4-cm-long, symmetrical, ovoid, poorly demarcated intramedullary expansion at C6-C7 that was T2-weighted hyperintense, T1-weighted isointense, and noncontrast enhancing. After clinical progression and euthanasia, pathology revealed a neoplasm composed of astrocytes and dysmorphic neurons, consistent with a ganglioglioma. The diagnosis was confirmed with immunohistochemistry and transmission electron microscopy, which demonstrated electron-dense granules in the perikaryon. Gangliogliomas are rare, benign neoplasms that may present as intramedullary spinal cord neoplasia. This is the first report on the clinical presentation, imaging, and pathology of a canine spinal ganglioglioma.

一只 7.5 岁雄性阉割德国牧羊犬的脊髓神经节胶质瘤的临床表现和磁共振成像结果。
一只狗在 1 个月前出现左侧偏瘫。核磁共振成像显示,C6-C7 处有一个 4 厘米长、对称、卵圆形、界限不清的髓内局灶性肿物,T2 加权高密度,T1 加权等密度,无对比增强。临床进展和安乐死后,病理检查发现肿瘤由星形胶质细胞和畸形神经元组成,与神经节胶质瘤一致。免疫组化和透射电子显微镜检查证实了这一诊断,结果显示神经节周围有电子致密颗粒。神经节胶质瘤是一种罕见的良性肿瘤,可能表现为髓内脊髓肿瘤。这是首次报道犬脊髓神经节胶质瘤的临床表现、影像学和病理学。
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来源期刊
Veterinary Radiology & Ultrasound
Veterinary Radiology & Ultrasound 农林科学-兽医学
CiteScore
2.40
自引率
17.60%
发文量
133
审稿时长
8-16 weeks
期刊介绍: Veterinary Radiology & Ultrasound is a bimonthly, international, peer-reviewed, research journal devoted to the fields of veterinary diagnostic imaging and radiation oncology. Established in 1958, it is owned by the American College of Veterinary Radiology and is also the official journal for six affiliate veterinary organizations. Veterinary Radiology & Ultrasound is represented on the International Committee of Medical Journal Editors, World Association of Medical Editors, and Committee on Publication Ethics. The mission of Veterinary Radiology & Ultrasound is to serve as a leading resource for high quality articles that advance scientific knowledge and standards of clinical practice in the areas of veterinary diagnostic radiology, computed tomography, magnetic resonance imaging, ultrasonography, nuclear imaging, radiation oncology, and interventional radiology. Manuscript types include original investigations, imaging diagnosis reports, review articles, editorials and letters to the Editor. Acceptance criteria include originality, significance, quality, reader interest, composition and adherence to author guidelines.
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