Recent progress in modeling and treating diabetes using stem cell-derived islets.

IF 5.4 2区 医学 Q1 CELL & TISSUE ENGINEERING
Marlie M Maestas, Maggie H Bui, Jeffrey R Millman
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引用次数: 0

Abstract

Stem cell-derived islets (SC-islets) offer the potential to be an unlimited source of cells for disease modeling and the treatment of diabetes. SC-islets can be genetically modified, treated with chemical compounds, or differentiated from patient derived stem cells to model diabetes. These models provide insights into disease pathogenesis and vulnerabilities that may be targeted to provide treatment. SC-islets themselves are also being investigated as a cell therapy for diabetes. However, the transplantation process is imperfect; side effects from immunosuppressant use have reduced SC-islet therapeutic potential. Alternative methods to this include encapsulation, use of immunomodulating molecules, and genetic modification of SC-islets. This review covers recent advances using SC-islets to understand different diabetes pathologies and as a cell therapy.

利用干细胞胰岛建模和治疗糖尿病的最新进展。
干细胞衍生胰岛(SC-islets)为疾病建模和糖尿病治疗提供了无限的细胞来源。干细胞衍生胰岛可通过基因改造、使用化合物处理或从患者衍生干细胞分化而来,从而建立糖尿病模型。通过这些模型,可以深入了解疾病的发病机制和弱点,从而有针对性地提供治疗。目前还在研究将SC-胰岛细胞本身作为糖尿病的细胞疗法。然而,移植过程并不完美;使用免疫抑制剂产生的副作用降低了SC-小鼠的治疗潜力。替代的方法包括封装、使用免疫调节分子以及对SC-小岛进行基因改造。本综述介绍了利用SC-小岛了解不同糖尿病病理和作为细胞疗法的最新进展。
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来源期刊
Stem Cells Translational Medicine
Stem Cells Translational Medicine CELL & TISSUE ENGINEERING-
CiteScore
12.90
自引率
3.30%
发文量
140
审稿时长
6-12 weeks
期刊介绍: STEM CELLS Translational Medicine is a monthly, peer-reviewed, largely online, open access journal. STEM CELLS Translational Medicine works to advance the utilization of cells for clinical therapy. By bridging stem cell molecular and biological research and helping speed translations of emerging lab discoveries into clinical trials, STEM CELLS Translational Medicine will help move applications of these critical investigations closer to accepted best patient practices and ultimately improve outcomes. The journal encourages original research articles and concise reviews describing laboratory investigations of stem cells, including their characterization and manipulation, and the translation of their clinical aspects of from the bench to patient care. STEM CELLS Translational Medicine covers all aspects of translational cell studies, including bench research, first-in-human case studies, and relevant clinical trials.
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