Clinical characteristics and outcomes of perinatal stroke in Australia: Population-based longitudinal study

IF 1.6 4区医学 Q2 PEDIATRICS

Journal of paediatrics and child health Pub Date : 2024-08-20 DOI:10.1111/jpc.16640

Bithi Roy, Annabel Webb, Karen Walker, Catherine Morgan, Nadia Badawi, Iona Novak

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Abstract

Aim

Perinatal stroke is one of the main causes of hemiplegia and seizure disorder. This study aimed to analyse the clinical characteristics and outcomes of perinatal stroke in a cohort of Australian children for its early detection.

Methods

A population-based prospective longitudinal study on perinatal stroke up to 2 years of age, was conducted from 2017 to 2019.

Results

Eighty-seven children with perinatal stroke included 79% (69/87) acute and 21% (18/87) presumed perinatal stroke. Seventy-four per cent (51/69) acute symptomatic perinatal strokes presented in the first 3 days of life and 78% (14/18) presumed perinatal strokes presented by 6 months of age. 62% had an arterial stroke, 29% had a venous stroke and 5% had a combined arterial and venous stroke. Unexpectedly, 35% (24/69) acute symptomatic perinatal stroke had only respiratory symptoms and 50% (9/18) presumed perinatal stroke were asymptomatic. The incidence of cerebral palsy was 29% (20/69) with acute symptomatic perinatal stroke and 72% (13/18) with presumed perinatal stroke.

Conclusions

The first week of a child's life is the most critical period in terms of lifelong disability from perinatal stroke. Recognising diverse clinical presentations will ensure early diagnosis and timely intervention treatments.

Abstract Image

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澳大利亚围产期中风的临床特征和预后：基于人口的纵向研究。

目的：围产期中风是导致偏瘫和癫痫发作的主要原因之一。本研究旨在分析澳大利亚儿童队列中围生期中风的临床特征和结果，以便及早发现：2017年至2019年，对2岁以下围产期中风患者进行了一项基于人群的前瞻性纵向研究：87名围产期中风患儿中，79%（69/87）为急性围产期中风，21%（18/87）为推测性围产期中风。74%（51/69）的急性无症状围产期中风患者在出生后 3 天内发病，78%（14/18）的推测围产期中风患者在 6 个月大前发病。62% 为动脉中风，29% 为静脉中风，5% 合并动脉和静脉中风。意想不到的是，35%（24/69）有症状的急性围产期中风只有呼吸道症状，50%（9/18）推测的围产期中风没有症状。急性无症状围产期中风的脑瘫发生率为 29%（20/69），推测为围产期中风的脑瘫发生率为 72%（13/18）：结论：婴儿出生后的第一周是围产期中风导致终身残疾的最关键时期。识别不同的临床表现可确保早期诊断和及时干预治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of paediatrics and child health 医学-小儿科

CiteScore

2.90

自引率

5.90%

发文量

487

审稿时长

3-6 weeks

期刊介绍： The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.