Photon-Counting Detector CT Radiological-Histological Correlation in Cadaveric Human Lung Nodules and Airways.

IF 7 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Investigative Radiology Pub Date : 2024-08-20 DOI:10.1097/RLI.0000000000001117

Akinori Hata, Masahiro Yanagawa, Keisuke Ninomiya, Noriko Kikuchi, Masako Kurashige, Chiaki Masuda, Tsubasa Yoshida, Daiki Nishigaki, Shuhei Doi, Kazuki Yamagata, Yuriko Yoshida, Ryo Ogawa, Yukiko Tokuda, Eiichi Morii, Noriyuki Tomiyama

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引用次数: 0

Abstract

Objectives: The aim of this study was to compare the performances of photon-counting detector computed tomography (PCD-CT) and energy-integrating detector computed tomography (EID-CT) for visualizing nodules and airways in human cadaveric lungs.

Materials and methods: Previously obtained 20 cadaveric lungs were scanned, and images were prospectively acquired by EID-CT and PCD-CT at a radiation dose with a noise level equivalent to the diagnostic reference level. PCD-CT was scanned with ultra-high-resolution mode. The EID-CT images were reconstructed with a 512 matrix, 0.6-mm thickness, and a 350-mm field of view (FOV). The PCD-CT images were reconstructed at 3 settings: PCD-512: same as EID-CT; PCD-1024-FOV350: 1024 matrix, 0.2-mm thickness, 350-mm FOV; and PCD-1024-FOV50: 1024 matrix, 0.2-mm thickness, 50-mm FOV. Two specimens per lung were examined after hematoxylin and eosin staining. The CT images were evaluated for nodules on a 5-point scale and for airways on a 4-point scale to compare the histology. The Wilcoxon signed rank test with Bonferroni correction was performed for statistical analyses.

Results: Sixty-seven nodules (1321 μm; interquartile range [IQR], 758-3105 μm) and 92 airways (851 μm; IQR, 514-1337 μm) were evaluated. For nodules and airways, scores decreased in order of PCD-1024-FOV50, PCD-1024-FOV350, PCD-512, and EID-CT. Significant differences were observed between series other than PCD-1024-FOV350 versus PCD-1024-FOV50 for nodules (PCD-1024-FOV350 vs PCD-1024-FOV50, P = 0.063; others P < 0.001) and between series other than EID-CT versus PCD-512 for airways (EID-CT vs PCD-512, P = 0.549; others P < 0.005). On PCD-1024-FOV50, the median size of barely detectable nodules was 604 μm (IQR, 469-756 μm) and that of barely detectable airways was 601 μm (IQR, 489-929 μm). On EID-CT, that of barely detectable nodules was 837 μm (IQR, 678-914 μm) and that of barely detectable airways was 1210 μm (IQR, 674-1435 μm).

Conclusions: PCD-CT visualized small nodules and airways better than EID-CT and improved with high spatial resolution and potentially can detect submillimeter nodules and airways.

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尸体肺结节和气道中的光子计数探测器 CT 放射组织学相关性。

研究目的本研究旨在比较光子计数探测器计算机断层扫描（PCD-CT）和能量积分探测器计算机断层扫描（EID-CT）在观察人体尸体肺部结节和气道方面的性能：对之前获得的 20 个尸体肺部进行扫描，并通过 EID-CT 和 PCD-CT 以相当于诊断参考水平的辐射剂量和噪声水平前瞻性地获取图像。PCD-CT 采用超高分辨率模式扫描。EID-CT 图像的重建矩阵为 512，厚度为 0.6 毫米，视场 (FOV) 为 350 毫米。PCD-CT 图像在 3 种设置下重建：PCD-512：与 EID-CT 相同；PCD-1024-FOV350：1024 矩阵，0.2 毫米厚度，350 毫米视场；PCD-1024-FOV50：1024 矩阵，0.2 毫米厚度，50 毫米视场。苏木精和伊红染色后，每个肺部检查两个标本。CT 图像的结节评估采用 5 级评分法，气道评估采用 4 级评分法，以比较组织学结果。统计分析采用 Wilcoxon 符号秩检验，并进行 Bonferroni 校正：评估了 67 个结节（1321 μm；四分位数间距 [IQR]，758-3105 μm）和 92 个气道（851 μm；IQR，514-1337 μm）。结节和气道的得分依次为 PCD-1024-FOV50、PCD-1024-FOV350、PCD-512 和 EID-CT。在结节方面，PCD-1024-FOV350 与 PCD-1024-FOV50 相比，PCD-1024-FOV350 与 PCD-1024-FOV50 相比，P = 0.063；其他 P <0.001）；在气道方面，EID-CT 与 PCD-512 相比，EID-CT 与 PCD-512 相比，P = 0.549；其他 P <0.005）。在 PCD-1024-FOV50 上，几乎检测不到的结节的中位尺寸为 604 μm（IQR，469-756 μm），几乎检测不到的气道的中位尺寸为 601 μm（IQR，489-929 μm）。在 EID-CT 上，几乎检测不到的结节为 837 μm（IQR，678-914 μm），几乎检测不到的气道为 1210 μm（IQR，674-1435 μm）：结论：与 EID-CT 相比，PCD-CT 对小结节和气道的可视化效果更好，空间分辨率更高，有可能检测到毫米以下的结节和气道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative Radiology 医学-核医学

CiteScore

15.10

自引率

16.40%

发文量

188

审稿时长

4-8 weeks

期刊介绍： Investigative Radiology publishes original, peer-reviewed reports on clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, and related modalities. Emphasis is on early and timely publication. Primarily research-oriented, the journal also includes a wide variety of features of interest to clinical radiologists.