Impact of cumulative dose of hydroxychloroquine on retinal structures.

IF 2.4 3区医学 Q2 OPHTHALMOLOGY

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-08-19 DOI:10.1007/s00417-024-06602-x

Andrea Montesel, Riccardo Sacconi, Paula La Rubia, Giuseppe Querques

引用次数: 0

Abstract

Key messages: What is known • Hydroxychloroquine (HCQ) is widely used for autoimmune disorders but is associated with the risk of retinal toxicity. • Early detection of retinal structural changes due to HCQ toxicity remains challenging, and cumulative HCQ dose as a risk factor has conflicting clinical relevance. What Is New • Higher cumulative HCQ doses are significantly associated with thinner outer retinal layers (foveal, parafoveal, and perifoveal regions). • No significant associations were found between HCQ cumulative dose and inner retinal thickness or age.

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羟氯喹累积剂量对视网膜结构的影响

关键信息：已知信息 - 羟氯喹（HCQ）被广泛用于治疗自身免疫性疾病，但与视网膜毒性的风险有关。- 早期检测HCQ毒性导致的视网膜结构变化仍具有挑战性，而将累积HCQ剂量作为风险因素与临床相关性存在冲突。新发现 - HCQ累积剂量越高，视网膜外层（眼窝、眼窝旁和眼窝周围区域）越薄。- HCQ累积剂量与视网膜内层厚度或年龄之间无明显关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Graefe’s Archive for Clinical and Experimental Ophthalmology 医学-眼科学

CiteScore

5.40

自引率

7.40%

发文量

398

审稿时长

3 months

期刊介绍： Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.