Epidemiology and clinical features of short-lasting unilateral neuralgiform headache attacks: A systematic review and meta-analysis.

IF 5 2区 医学 Q1 CLINICAL NEUROLOGY
Johanne Gry Larsen, Mikkel Johannes Henningsen, William Kristian Karlsson, Rune Häckert Christensen, Haidar Muhsen Al-Khazali, Faisal Mohammad Amin, Håkan Ashina
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Abstract

Background: To synthesize the available epidemiologic data on short-lasting unilateral neuralgiform headache attacks (SUNHA). This, in turn, might inform diagnostic work-up and clinical decision-making.

Methods: EMBASE and PubMed were searched for observational studies reporting on the prevalence or relative frequency of SUNHA or its individual clinical features. Two investigators independently conducted title and abstract screening, full-text review, data extraction, and risk of bias assessment, and random-effects meta-analyses were performed to estimate the prevalence or relative frequency of SUNHA and its individual clinical features.

Results: Fifteen clinic-based studies met our eligibility criteria. Of these, five studies reported estimates on the relative frequency of SUNHA among adults evaluated for headache or facial pain, yielding a pooled relative frequency as 0.32% (95% confidence interval = 0.17-0.62; I2= 89.9%). Most often, SUNHA presented as episodic, side-locked stabbing headache of severe pain intensity, predominantly affecting the ophthalmic and/or maxillary branch of the trigeminal nerve. The most common cranial autonomic features were lacrimation, conjunctival injection, rhinorrhea and nasal congestion.

Conclusions: SUNHA is a rare headache disorder with distinct clinical features. However, our findings must be interpreted with caution as a result of between-study heterogeneity and lack of population-based studies, underscoring the need for further epidemiologic research.

短时单侧神经痛发作的流行病学和临床特征:系统回顾和荟萃分析。
背景:综合现有的关于短程单侧神经样头痛发作(SUNHA)的流行病学数据,从而为诊断工作和临床决策提供依据。方法:在 EMBASE 和 PubMed 上检索了有关短时单侧神经样头痛发作及其相关的观察性研究:方法:检索 EMBASE 和 PubMed,查找报告 SUNHA 发病率或相对频率或其个别临床特征的观察性研究。两名研究人员独立进行了标题和摘要筛选、全文审阅、数据提取和偏倚风险评估,并进行了随机效应荟萃分析,以估算 SUNHA 及其个别临床特征的流行率或相对频率:结果:15 项临床研究符合我们的资格标准。其中,五项研究报告了因头痛或面部疼痛而接受评估的成人中 SUNHA 的相对发生率,得出的汇总相对发生率为 0.32%(95% 置信区间 = 0.17-0.62;I2 = 89.9%)。大多数情况下,SUNHA表现为阵发性、侧锁性、剧烈刺痛的头痛,主要影响三叉神经的眼支和/或上颌支。最常见的颅内自主神经特征是流泪、结膜注射、鼻出血和鼻塞:结论:SUNHA 是一种罕见的头痛疾病,具有独特的临床特征。结论:SUNHA 是一种罕见的头痛疾病,具有独特的临床特征,但由于研究间的异质性和缺乏以人群为基础的研究,我们的研究结果必须谨慎解读,这凸显了进一步开展流行病学研究的必要性。
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来源期刊
Cephalalgia
Cephalalgia 医学-临床神经学
CiteScore
10.10
自引率
6.10%
发文量
108
审稿时长
4-8 weeks
期刊介绍: Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.
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