The potential longevity-promoting hypoxic-hypercapnic environment as a measure for radioprotection.

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI:10.1007/s10522-024-10129-3

Elroei David, Marina Wolfson, Khachik K Muradian, Vadim E Fraifeld

引用次数: 0

Abstract

Many biological mechanisms of aging well converge with radiation's biological effects. We used scientific insights from the field of aging to establish a novel hypoxic-hypercapnic environment (HHE) concept for radioprotection. According to this concept, HHE which possesses an anti-aging and longevity-promoting potential, should also act as a radiomitigator and radioprotector. As such, it might contribute greatly to the safety and wellbeing of individuals exposed to high levels of radiation, whether in planned events (e.g. astronauts) or in unplanned events (e.g. first responders in nuclear accidents).

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作为放射防护措施的潜在长寿促进缺氧-高二氧化碳浓度环境。

许多衰老的生物机制与辐射的生物效应相吻合。我们利用衰老领域的科学见解，建立了一种新的缺氧-高碳酸环境（HHE）辐射防护概念。根据这一概念，具有抗衰老和促进长寿潜能的缺氧-高碳酸环境还应该是一种辐射诱导剂和辐射防护剂。因此，无论是在计划内事件（如宇航员）还是在计划外事件（如核事故中的第一反应人员）中，它都可能极大地促进暴露于高水平辐射的个人的安全和福祉。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.