Reduced order modelling of intracranial aneurysm flow using proper orthogonal decomposition and neural networks

IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Michael MacRaild, Ali Sarrami-Foroushani, Toni Lassila, Alejandro F. Frangi
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Abstract

Reduced order modelling (ROMs) methods, such as proper orthogonal decomposition (POD), systematically reduce the dimensionality of high-fidelity computational models and potentially achieve large gains in execution speed. Machine learning (ML) using neural networks has been used to overcome limitations of traditional ROM techniques when applied to nonlinear problems, which has led to the recent development of reduced order models augmented by machine learning (ML-ROMs). However, the performance of ML-ROMs is yet to be widely evaluated in realistic applications and questions remain regarding the optimal design of ML-ROMs. In this study, we investigate the application of a non-intrusive parametric ML-ROM to a nonlinear, time-dependent fluid dynamics problem in a complex 3D geometry. We construct the ML-ROM using POD for dimensionality reduction and neural networks for interpolation of the ROM coefficients. We compare three different network designs in terms of approximation accuracy and performance. We test our ML-ROM on a flow problem in intracranial aneurysms, where flow variability effects are important when evaluating rupture risk and simulating treatment outcomes. The best-performing network design in our comparison used a two-stage POD reduction, a technique rarely used in previous studies. The best-performing ROM achieved mean test accuracies of 98.6% and 97.6% in the parent vessel and the aneurysm, respectively, while providing speed-up factors of the order 10 5 .

Abstract Image

利用适当的正交分解和神经网络建立颅内动脉瘤血流的低阶模型。
适当正交分解(POD)等降阶建模(ROMs)方法可系统地降低高保真计算模型的维度,并有可能大幅提高执行速度。使用神经网络的机器学习(ML)已被用于克服传统 ROM 技术在应用于非线性问题时的局限性,这导致了最近由机器学习增强的降序模型(ML-ROMs)的发展。然而,ML-ROMs 的性能尚未在实际应用中得到广泛评估,ML-ROMs 的优化设计问题依然存在。在本研究中,我们研究了将非侵入式参数化 ML-ROM 应用于复杂三维几何中的非线性、随时间变化的流体动力学问题。我们使用 POD 方法构建 ML-ROM 以降低维度,并使用神经网络对 ROM 系数进行插值。我们比较了三种不同网络设计的逼近精度和性能。我们在颅内动脉瘤的流动问题上测试了我们的 ML-ROM,流动变异效应在评估破裂风险和模拟治疗结果时非常重要。在我们的比较中,表现最好的网络设计使用了两阶段 POD 缩减,这是以前的研究中很少使用的技术。表现最好的 ROM 在母血管和动脉瘤中的平均测试准确率分别达到了 98.6% 和 97.6%,同时提供了 10 5 $$ {10}^5 $$ 数量级的加速因子。
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来源期刊
International Journal for Numerical Methods in Biomedical Engineering
International Journal for Numerical Methods in Biomedical Engineering ENGINEERING, BIOMEDICAL-MATHEMATICAL & COMPUTATIONAL BIOLOGY
CiteScore
4.50
自引率
9.50%
发文量
103
审稿时长
3 months
期刊介绍: All differential equation based models for biomedical applications and their novel solutions (using either established numerical methods such as finite difference, finite element and finite volume methods or new numerical methods) are within the scope of this journal. Manuscripts with experimental and analytical themes are also welcome if a component of the paper deals with numerical methods. Special cases that may not involve differential equations such as image processing, meshing and artificial intelligence are within the scope. Any research that is broadly linked to the wellbeing of the human body, either directly or indirectly, is also within the scope of this journal.
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