Nurturing Longitudinal Samples 2.0.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI:10.1177/01939459241273328

Alexa K Stuifbergen, Heather Becker, Vicki Kullberg, Oxana Palesh, Shelli R Kesler

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引用次数: 0

Abstract

Background: While longitudinal designs can provide significant advantages compared to single measurement/cross sectional designs, they require careful attention to study infrastructure and the risk of attrition among the sample over multiple time points.

Objective: The strategies used to design and manage an appropriate infrastructure for a longitudinal study and approaches to retain samples are explored using examples from 2 studies, a 25-year study of persons living with multiple sclerosis and a 10-year longitudinal follow-up of breast cancer survivors.

Results: Key strategies (developing appropriate infrastructure, minimizing costs to participants, and maximizing rewards of study participation) have helped address the serious threat of attrition in these longitudinal samples.

Conclusion: Implementation of these strategies can help mitigate some of the disadvantages and leverage the strengths of longitudinal research to produce reliable, insightful, and impactful outcomes.

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培育纵向样本 2.0。

背景：尽管纵向设计与单一测量/横断面设计相比具有显著优势，但纵向设计需要仔细关注研究基础设施以及多个时间点样本流失的风险：尽管纵向设计与单一测量/横断面设计相比具有显著优势，但纵向设计需要仔细关注研究基础设施以及多个时间点样本自然减员的风险：目的：以两项研究为例，探讨为纵向研究设计和管理适当基础设施的策略，以及保留样本的方法，这两项研究分别是对多发性硬化症患者进行的为期 25 年的研究，以及对乳腺癌幸存者进行的为期 10 年的纵向随访：结果：关键策略（开发适当的基础设施、最大限度地降低参与者的成本以及最大限度地提高参与研究的回报）有助于解决这些纵向样本流失的严重威胁：结论：实施这些策略有助于减轻纵向研究的一些不利因素，并利用纵向研究的优势产生可靠、有洞察力和有影响力的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464