Shefali Mishra, Sujata R Kanetkar, Kailas D Datkhile
{"title":"Expression of caveolin 1 in oral squamous cell carcinoma.","authors":"Shefali Mishra, Sujata R Kanetkar, Kailas D Datkhile","doi":"10.4103/jomfp.jomfp_310_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Caveolin-1 is a surface protein that is a major structural component of caveolae, which are vesicles of the plasma membrane integral to a variety of signal transduction molecules and transport functions. Caveolin-1 is a biomarker undergoing research & studies have shown an increased expression of Cav-1 in the stepwise carcinogenesis from the normal oral mucosa, hyperplastic mucosa, dysplastic mucosa, precancerous lesions to Oral Squamous Cell Carcinoma. In the present study Correlation between Caveolin-1 expression and grade of tumor was established statistically.</p><p><strong>Aims: </strong>To study immunohistochemical expression of Caveolin-1 in Oral Squamous Cell Carcinoma.</p><p><strong>Settings and design: </strong>Cross sectional study carried out in a tertiary care hospital.</p><p><strong>Materials and methods: </strong>A total of 90 cases of histopathologically diagnosed oral squamous cell carcinoma was evaluated. Grading of the cases into well, moderate and poorly differentiated carcinomas was done as per WHO guidelines . Margin and lymph node status were evaluated. Anti- Caveolin-1 antibody (E249)- Caveolae marker ab32577 was used in the dilution of 1:100. Results were expressed taking reference of the methodology used by Hung et al 2003.</p><p><strong>Statistical analysis used: </strong>Statistical Package for the Social Sciences (SPSS 25.0).</p><p><strong>Results: </strong>Correlation of tumor grade and lymph node metastasis was statistically significant <i>p</i>=0.0006. There was a significant statistical correlation between tumor grade and immunohistochemical expression of Caveolin-1, <i>p</i>- value=0.00. Correlation between Lymph node metastasis and Caveolin-1 was statistically significant, <i>p</i>-value=0.008.</p><p><strong>Conclusions: </strong>Caveolin-1 expression correlates with aggressive tumor behavior and poor prognostic outcome.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"200-204"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329077/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral and Maxillofacial Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jomfp.jomfp_310_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Context: Caveolin-1 is a surface protein that is a major structural component of caveolae, which are vesicles of the plasma membrane integral to a variety of signal transduction molecules and transport functions. Caveolin-1 is a biomarker undergoing research & studies have shown an increased expression of Cav-1 in the stepwise carcinogenesis from the normal oral mucosa, hyperplastic mucosa, dysplastic mucosa, precancerous lesions to Oral Squamous Cell Carcinoma. In the present study Correlation between Caveolin-1 expression and grade of tumor was established statistically.
Aims: To study immunohistochemical expression of Caveolin-1 in Oral Squamous Cell Carcinoma.
Settings and design: Cross sectional study carried out in a tertiary care hospital.
Materials and methods: A total of 90 cases of histopathologically diagnosed oral squamous cell carcinoma was evaluated. Grading of the cases into well, moderate and poorly differentiated carcinomas was done as per WHO guidelines . Margin and lymph node status were evaluated. Anti- Caveolin-1 antibody (E249)- Caveolae marker ab32577 was used in the dilution of 1:100. Results were expressed taking reference of the methodology used by Hung et al 2003.
Statistical analysis used: Statistical Package for the Social Sciences (SPSS 25.0).
Results: Correlation of tumor grade and lymph node metastasis was statistically significant p=0.0006. There was a significant statistical correlation between tumor grade and immunohistochemical expression of Caveolin-1, p- value=0.00. Correlation between Lymph node metastasis and Caveolin-1 was statistically significant, p-value=0.008.
Conclusions: Caveolin-1 expression correlates with aggressive tumor behavior and poor prognostic outcome.
期刊介绍：
The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.
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