Emerging Perspectives on Neuroprotection.

IF 16.3 1区医学 Q1 PSYCHIATRY

Psychotherapy and Psychosomatics Pub Date : 2024-08-16 DOI:10.1159/000540032

Gregor Hasler, Dragos Inta

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引用次数: 0

Abstract

Neuroprotection aims to safeguard neurons from damage caused by various factors like stress, potentially leading to the rescue, recovery, or regeneration of the nervous system and its functions [J Clin Neurosci. 2002;9(1):4-8]. Conversely, neuroplasticity refers to the brain's ability to adapt and change throughout life, involving structural and functional alterations in cells and synaptic transmission [Neural Plast. 2014;2014:541870]. Neuroprotection is a broad and multidisciplinary field encompassing various approaches and strategies aimed at preserving and promoting neuronal health. It is a critical area of research in neuroscience and neurology, with the potential to lead to new therapies for a wide range of neurological disorders and conditions. Neuroprotection can take various forms and may involve pharmacological agents, lifestyle modifications, or behavioral interventions. Accordingly, also the perspective and the meaning of neuroprotection differs due to different angles of interpretation. The primary interpretation is from the pharmacological point of view since the most consistent data come from this field. In addition, we will discuss also alternative, yet less considered, perspectives on neuroprotection, focusing on specific neuroprotective targets, interactions with surrounding microglia, different levels of neuroprotective effects, the reversive/adaptative dimension, and its use as anticipatory/prophylactic intervention.

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神经保护的新视角

神经保护的目的是保护神经元免受压力等各种因素的损害，从而可能导致神经系统及其功能的挽救、恢复或再生[J Clin Neurosci. 2002;9(1):4-8]。相反，神经可塑性指的是大脑在整个生命过程中的适应和变化能力，涉及细胞和突触传递的结构和功能改变[Neural Plast.2014;2014:541870]。神经保护是一个广泛的多学科领域，包括旨在保护和促进神经元健康的各种方法和策略。它是神经科学和神经病学的一个重要研究领域，有可能为多种神经系统疾病和病症带来新疗法。神经保护的形式多种多样，可能涉及药物、生活方式调整或行为干预。因此，神经保护的视角和含义也因解释角度的不同而不同。我们主要从药理学的角度进行解释，因为这一领域的数据最为一致。此外，我们还将讨论神经保护的其他视角（但考虑较少），重点关注特定的神经保护靶点、与周围小胶质细胞的相互作用、不同程度的神经保护效应、逆转/适应维度，以及其作为预期/预防性干预的用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychotherapy and Psychosomatics 医学-精神病学

CiteScore

29.40

自引率

6.10%

发文量

期刊介绍： Psychotherapy and Psychosomatics is a reputable journal that has been published since 1953. Over the years, it has gained recognition for its independence, originality, and methodological rigor. The journal has been at the forefront of research in psychosomatic medicine, psychotherapy research, and psychopharmacology, and has contributed to the development of new lines of research in these areas. It is now ranked among the world's most cited journals in the field. As the official journal of the International College of Psychosomatic Medicine and the World Federation for Psychotherapy, Psychotherapy and Psychosomatics serves as a platform for discussing current and controversial issues and showcasing innovations in assessment and treatment. It offers a unique forum for cutting-edge thinking at the intersection of medical and behavioral sciences, catering to both practicing clinicians and researchers. The journal is indexed in various databases and platforms such as PubMed, MEDLINE, Web of Science, Science Citation Index, Social Sciences Citation Index, Science Citation Index Expanded, BIOSIS Previews, Google Scholar, Academic Search, and Health Research Premium Collection, among others.

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