Association Between Remnant Cholesterol and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis.

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Metabolic syndrome and related disorders Pub Date : 2024-11-01 Epub Date: 2024-08-19 DOI:10.1089/met.2024.0042
Jiake Tang, Ting Tang, Qingwen Yu, Xuhan Tong, Chun Liu, Chen Chen, Siqi Hu, Shenghui Zhang, Yao You, Chunyi Wang, Jie Li, Wen Wen, Juan Chen, Xingwei Zhang, Mingwei Wang, Fan Tong
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引用次数: 0

Abstract

Lipid disorders are related to the risk of nonalcoholic fatty liver disease (NAFLD). Remnant cholesterol (RC), a nonclassical and once-neglected risk factor for NAFLD, has recently received new attention. In this study, we assessed the relationship between the RC levels and NAFLD risk. We searched across PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure, with no restrictions on publication languages. Retrospective cohort studies and cross-sectional studies were enrolled from the inception of the databases until August 6, 2023. A random-effect model was applied to construct the mean difference, and a 95% confidence interval was applied to assess the relationship between the RC levels and NAFLD risk. We used two methods to estimate RC levels: Calculated-1 subtracts low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol from total cholesterol; Calculated-2 uses the Friedewald formula for LDL-C when triglycerides are <4.0 mmol/L, otherwise directly measured. A total of 265 published studies were selected through preliminary retrieval. Of these, six studies met the inclusion requirements and were enrolled in the meta-analysis. The RC level in the NAFLD group was significantly higher than that in the non-NAFLD group (mean difference: 0.18, 95% confidence interval: 0.10-0.26, P < 0.00001). We conducted subgroup analyses of computational methods and geographic regions. Notably, in the subgroup analysis of Calculation Method 2, the NAFLD group had significantly higher RC levels than the non-NAFLD group. On the other hand, in Calculation Method 1, the difference between the two groups was insignificant. In both the Asian and non-Asian populations, the RC levels were significantly higher in the NAFLD group than in the non-NAFLD group. The association of RC with an increased NAFLD risk was not dependent on the triglyceride. This meta-analysis suggests that elevated RC levels are associated with an increased risk of NAFLD. In addition to the conventional risk factors for fatty liver, clinicians should be concerned about the RC levels in the clinic.

残余胆固醇与非酒精性脂肪肝之间的关系:系统回顾与元分析》。
血脂紊乱与非酒精性脂肪肝(NAFLD)的风险有关。残余胆固醇(RC)是一种非典型的非酒精性脂肪肝风险因素,曾一度被忽视,最近又受到了新的关注。在本研究中,我们评估了残余胆固醇水平与非酒精性脂肪肝风险之间的关系。我们在 PubMed、Web of Science、Embase、Cochrane Library 和中国国家知识基础设施中进行了检索,对发表语言没有限制。从数据库建立之初到 2023 年 8 月 6 日,我们纳入了回顾性队列研究和横断面研究。采用随机效应模型构建平均差,并采用95%置信区间评估RC水平与非酒精性脂肪肝风险之间的关系。我们采用两种方法估算 RC 水平:计算-1 从总胆固醇中减去低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇;计算-2 在甘油三酯 P < 0.00001 时使用弗里德瓦尔德公式计算 LDL-C)。我们对计算方法和地理区域进行了亚组分析。值得注意的是,在计算方法 2 的亚组分析中,非酒精性脂肪肝组的 RC 水平明显高于非非酒精性脂肪肝组。另一方面,在计算方法 1 中,两组之间的差异并不显著。在亚裔和非亚裔人群中,非酒精性脂肪肝组的 RC 水平明显高于非非酒精性脂肪肝组。RC与非酒精性脂肪肝风险增加的关系与甘油三酯无关。这项荟萃分析表明,RC水平升高与非酒精性脂肪肝风险增加有关。除了脂肪肝的传统风险因素外,临床医生还应关注临床中的 RC 水平。
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来源期刊
Metabolic syndrome and related disorders
Metabolic syndrome and related disorders MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.40
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: Metabolic Syndrome and Related Disorders is the only peer-reviewed journal focusing solely on the pathophysiology, recognition, and treatment of this major health condition. The Journal meets the imperative for comprehensive research, data, and commentary on metabolic disorder as a suspected precursor to a wide range of diseases, including type 2 diabetes, cardiovascular disease, stroke, cancer, polycystic ovary syndrome, gout, and asthma. Metabolic Syndrome and Related Disorders coverage includes: -Insulin resistance- Central obesity- Glucose intolerance- Dyslipidemia with elevated triglycerides- Low HDL-cholesterol- Microalbuminuria- Predominance of small dense LDL-cholesterol particles- Hypertension- Endothelial dysfunction- Oxidative stress- Inflammation- Related disorders of polycystic ovarian syndrome, fatty liver disease (NASH), and gout
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