Efficacy and Safety of 125I Seed Implantation in the Treatment of Pelvic Recurrent Cervical Cancer Following Radiotherapy: A Single-Arm Meta-Analysis of Chinese Patients

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-19 DOI:10.1002/cnr2.2147

Yunxin Wang, Yuhong Ma, Lijuan Zou, Hongwei Lei, Yun Teng, Fuxiu Ye, Feng Zhang, Haichen Zhang

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Abstract

Background

The study aimed to assess the efficacy and safety of ¹²⁵I seed implantation in the treatment of pelvic recurrent cervical cancer following radiotherapy. This meta-analysis was registered in PROSPERO. We looked up relevant studies in the databases of CNKI, Wanfang, CBM, PubMed, Embase, Cochrane Library, and Web of Science. The endpoint measures include the objective response rate, disease control rate, progression-free survival, overall survival, and adverse events.

Recent Fidings

The meta-analysis included six studies and a total of 246 patients. The pooled ORR of tumor response was 63%, and the DCR was 87%. The median PFS was 9.09 months, and the median OS was 13.46 months. The incidence of adverse events of Grade ≥III was 6%.

Conclusion

In conclusion, this meta-analysis confirmed that ¹²⁵I seed implantation has a good local control rate and high safety in the treatment of pelvic recurrent cervical cancer following radiotherapy, and can be used as a remedial treatment for pelvic recurrent cervical cancer following radiotherapy to prolong the survival time of patients.

Trial Registration

PROSPERO: CRD42023423857

Abstract Image

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125I粒子植入治疗放疗后盆腔复发性宫颈癌的有效性和安全性：中国患者的单臂Meta分析

研究背景该研究旨在评估 125I 粒子植入治疗放疗后盆腔复发宫颈癌的有效性和安全性。该荟萃分析已在 PROSPERO 上注册。我们在 CNKI、万方数据库、CBM、PubMed、Embase、Cochrane Library 和 Web of Science 等数据库中查找了相关研究。终点指标包括客观反应率、疾病控制率、无进展生存期、总生存期和不良事件：荟萃分析包括六项研究，共有 246 名患者。肿瘤反应的汇总 ORR 为 63%，DCR 为 87%。中位 PFS 为 9.09 个月，中位 OS 为 13.46 个月。≥III级不良反应发生率为6%：总之，该荟萃分析证实，125I粒子植入治疗放疗后盆腔复发宫颈癌具有良好的局部控制率和较高的安全性，可作为放疗后盆腔复发宫颈癌的补救治疗方法，延长患者的生存时间：试验注册：PROCROPERO：CRD42023423857。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.