A Bibliometric Analysis of Metabolic Reprogramming in the Tumor Microenvironment From 2003 to 2022

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-19 DOI:10.1002/cnr2.2146

Yupeng Xi, Rui Liu, Xing Zhang, Qiujun Guo, Xiwen Zhang, Zizhen Yang, Honggang Zheng, Qingqiao Song, Baojin Hua

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引用次数: 0

Abstract

Background

Despite considerable progress in cancer immunotherapy, it is not available for many patients. Resistance to immune checkpoint blockers arises from the intricate interactions between cancer and its microenvironment. Metabolic reprogramming in tumor and immune cells in the tumor microenvironment (TME) influences anti-tumor immune responses by remodeling the immune microenvironment. Metabolic reprogramming has emerged as an important hallmark of tumorigenesis. However, few studies have focused on the TME and metabolic reprogramming. Therefore, we aimed to explore the current research status and popular topics in TME-related metabolic reprogramming over a 20 years using a bibliometric approach.

Methods

Studies focusing on metabolic reprogramming and TME were searched using the Web of Science Core Collection database. Bibliometric and visual analyses of the articles and reviews were performed using Bibliometrix, VOSviewer, and CiteSpace.

Results

In total, 4726 articles published between 2003 and 2022 were selected. The number of publications and citations has increased annually. Cooperation network analysis indicated that the United States holds the foremost position in metabolic reprogramming and TME research with the highest volume of publications and citations, thus exerting the greatest influence. Among these institutions, Fudan University displayed the highest level of productivity. Frontiers in Immunology showed the highest degree of productivity in this field. Ho Ping-Chih made the most article contributions, and Pearce Edward J. was the most co-cited author. Four clusters were obtained after a cluster analysis of the authors' keywords: TME, metabolic reprogramming, immunometabolism, and immunity. Immunometabolism, glycolysis, immune cells, and tumor-associated macrophages are relatively recent keywords that have attracted increasing attention.

Conclusions

A comprehensive landscape of advancements in metabolic reprogramming and the TME was evaluated, which provided crucial information for scholars to further advance this promising field. Further research should explore new topics related to immunometabolism in the TME using a transdisciplinary approach.

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2003年至2022年肿瘤微环境代谢重编程的文献计量分析

背景：尽管癌症免疫疗法取得了相当大的进展，但许多患者仍无法接受这种疗法。免疫检查点阻断剂的抗药性源于癌症与其微环境之间错综复杂的相互作用。肿瘤微环境（TME）中肿瘤和免疫细胞的代谢重编程通过重塑免疫微环境来影响抗肿瘤免疫反应。代谢重编程已成为肿瘤发生的一个重要标志。然而，很少有研究关注 TME 和代谢重编程。因此，我们旨在采用文献计量学方法，探讨20年来TME相关代谢重编程的研究现状和热门话题：方法：使用 Web of Science Core Collection 数据库检索有关代谢重编程和 TME 的研究。使用 Bibliometrix、VOSviewer 和 CiteSpace 对文章和综述进行文献计量学和视觉分析：结果：共选取了 2003 年至 2022 年间发表的 4726 篇文章。论文数量和引用次数逐年增加。合作网络分析显示，美国在代谢重编程和TME研究领域居于首位，论文发表量和被引用次数最多，因此影响力最大。在这些机构中，复旦大学的生产力水平最高。免疫学前沿（Frontiers in Immunology）在该领域的生产力水平最高。何秉志的文章贡献最多，Pearce Edward J. 是被联合引用最多的作者。在对作者关键词进行聚类分析后，得出了四个聚类：TME、代谢重编程、免疫代谢和免疫。免疫代谢、糖酵解、免疫细胞和肿瘤相关巨噬细胞是相对较新的关键词，已引起越来越多的关注：本文对代谢重编程和肿瘤细胞生长因子的研究进展进行了全面评估，为学者们进一步推动这一前景广阔的领域提供了重要信息。进一步的研究应采用跨学科的方法探索与肿瘤坏死组织中免疫代谢相关的新课题。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.