Trends in pancreatic cancer mortality in the United States 1999-2020: a CDC database population-based study.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Causes & Control Pub Date : 2024-12-01 Epub Date: 2024-08-19 DOI:10.1007/s10552-024-01906-z

Alexander J Didier, Swamroop Nandwani, Alan M Fahoury, Daniel J Craig, Dean Watkins, Andrew Campbell, Caleb T Spencer, Macelyn Batten, Divya Vijendra, Jeffrey M Sutton

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Abstract

Introduction: Pancreatic cancer is a significant public health concern and a leading cause of cancer-related deaths worldwide. This study aimed to investigate pancreatic cancer mortality trends and disparities in the United States (US) from 1999 to 2020.

Methods: Data were obtained from the Centers for Disease Control (CDC) Wide-Ranging Online Data for Epidemiologic Research database. Mortality rates were age-adjusted and standardized to the year 2000 US population. Joinpoint regression was used to analyze temporal trends in age-adjusted mortality rates (AAMRs) by sociodemographic and geographic variables.

Results: Between 1999 and 2020, pancreatic cancer led to a total of 810,628 deaths in the US, an average mortality of nearly 39,000 deaths per year. The AAMR slightly increased from 10.6 in 1999 to 11.1 in 2020, with an associated annual percent change (APC) of 0.2. Mortality rates were highest among individuals aged 65 and older. Black individuals experienced the highest overall pancreatic cancer-related AAMR at 13.8. Despite this, Black individuals experienced a decreasing mortality trend over time (APC -0.2) while White individuals experienced an increasing trend in mortality (APC 0.4). Additionally, individuals residing in rural areas experienced steeper rates of mortality increase than those living in urban areas (APC 0.6 for rural vs -0.2 for urban). White individuals in urban and rural populations experienced an increase in mortality, while Black individuals in urban environments experienced a decrease in mortality, and Black individuals in rural environments experienced stable mortality trends.

Conclusions: Mortality from pancreatic cancer continues to increase in the US, with racial and regional disparities identified in minorities and rural-dwelling individuals. These disparate findings highlight the importance of ongoing efforts to understand and address pancreatic cancer treatment and outcomes disparities in the US, and future studies should further investigate the underlying etiologies of these disparities and potential for novel therapies to reduce the mortality.

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1999-2020 年美国胰腺癌死亡率趋势：疾病预防控制中心数据库人口研究。

导言：胰腺癌是一个重大的公共卫生问题，也是全球癌症相关死亡的主要原因。本研究旨在调查 1999 年至 2020 年美国的胰腺癌死亡率趋势和差异：数据来自美国疾病控制中心（CDC）的流行病学研究广泛在线数据数据库。死亡率经过年龄调整，并以 2000 年美国人口为标准。连接点回归用于分析按社会人口和地理变量划分的年龄调整死亡率（AAMRs）的时间趋势：结果：1999 年至 2020 年间，美国共有 810,628 人死于胰腺癌，平均每年死亡近 39,000 人。美国胰腺癌死亡率从 1999 年的 10.6 略微上升至 2020 年的 11.1，相关的年百分比变化 (APC) 为 0.2。65 岁及以上人群的死亡率最高。黑人与胰腺癌相关的总体死亡率最高，为 13.8。尽管如此，随着时间的推移，黑人的死亡率呈下降趋势（APC -0.2），而白人的死亡率呈上升趋势（APC 0.4）。此外，居住在农村地区的人比居住在城市地区的人的死亡率上升幅度更大（农村地区的 APC 为 0.6，而城市地区的 APC 为-0.2）。城市和农村人口中的白人死亡率上升，而城市环境中的黑人死亡率下降，农村环境中的黑人死亡率趋势稳定：结论：在美国，胰腺癌的死亡率持续上升，在少数民族和农村居民中发现了种族和地区差异。这些不同的研究结果凸显了美国持续努力了解和解决胰腺癌治疗和结果差异的重要性，未来的研究应进一步调查这些差异的潜在病因以及降低死亡率的新型疗法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生

CiteScore

3.90

自引率

4.30%

发文量

130

审稿时长

6.6 months

期刊介绍： Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.