Targeting the epigenome with advanced delivery strategies for epigenetic modulators

IF 6.1 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Sonia Guha, Yogeswaran Jagadeesan, Murali Monohar Pandey, Anupama Mittal, Deepak Chitkara
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引用次数: 0

Abstract

Epigenetics mechanisms play a significant role in human diseases by altering DNA methylation status, chromatin structure, and/or modifying histone proteins. By modulating the epigenetic status, the expression of genes can be regulated without any change in the DNA sequence itself. Epigenetic drugs exhibit promising therapeutic efficacy against several epigenetically originated diseases including several cancers, neurodegenerative diseases, metabolic disorders, cardiovascular disorders, and so forth. Currently, a considerable amount of research is focused on discovering new drug molecules to combat the existing research gap in epigenetic drug therapy. A novel and efficient delivery system can be established as a promising approach to overcome the drawbacks associated with the current epigenetic modulators. Therefore, formulating the existing epigenetic drugs with distinct encapsulation strategies in nanocarriers, including solid lipid nanoparticles, nanogels, bio‐engineered nanocarriers, liposomes, surface modified nanoparticles, and polymer–drug conjugates have been examined for therapeutic efficacy. Nonetheless, several epigenetic modulators are untouched for their therapeutic potential through different delivery strategies. This review provides a comprehensive up to date discussion on the research findings of various epigenetics mechanism, epigenetic modulators, and delivery strategies utilized to improve their therapeutic outcome. Furthermore, this review also highlights the recently emerged CRISPR tool for epigenome editing.
以表观基因组为目标,采用先进的表观遗传调节剂递送策略
表观遗传学机制通过改变 DNA 甲基化状态、染色质结构和/或修饰组蛋白,在人类疾病中发挥着重要作用。通过调节表观遗传状态,可以在不改变 DNA 序列本身的情况下调节基因的表达。表观遗传药物对几种由表观遗传引起的疾病,包括几种癌症、神经退行性疾病、代谢紊乱、心血管疾病等具有良好的疗效。目前,大量研究都集中在发现新的药物分子上,以填补表观遗传药物治疗领域现有的研究空白。建立新颖高效的给药系统是克服现有表观遗传调节剂弊端的有效方法。因此,研究人员采用不同的封装策略将现有的表观遗传药物配制成纳米载体,包括固体脂质纳米颗粒、纳米凝胶、生物工程纳米载体、脂质体、表面修饰纳米颗粒和聚合物-药物共轭物,以研究其疗效。然而,还有一些表观遗传调节剂尚未通过不同的递送策略发挥其治疗潜力。本综述对各种表观遗传学机制、表观遗传学调节剂以及用于改善治疗效果的给药策略的研究成果进行了全面的最新讨论。此外,本综述还重点介绍了最近出现的用于表观基因组编辑的 CRISPR 工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Bioengineering & Translational Medicine
Bioengineering & Translational Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
8.40
自引率
4.10%
发文量
150
审稿时长
12 weeks
期刊介绍: Bioengineering & Translational Medicine, an official, peer-reviewed online open-access journal of the American Institute of Chemical Engineers (AIChE) and the Society for Biological Engineering (SBE), focuses on how chemical and biological engineering approaches drive innovative technologies and solutions that impact clinical practice and commercial healthcare products.
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