Neuroprotective effect of Myrtus communis against ionizing radiation-induced brain injury: Insights from histopathological and biochemical analysis in rats

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences Pub Date : 2024-08-17 DOI:10.1016/j.jrras.2024.101082

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引用次数: 0

Abstract

Aim

To investigate the potential radioprotective effects of Myrtus communis on brain tissue.

Methods

Thirty female rats were divided into four groups. The control group (C) was applied with oral saline solution (SF) for four days. Myrtus communis (MC) groups started to receive MC (100 mg/kg, oral) either four days before (R + preMC) or immediately after (R + MC) irradiation for four days. Irradiation was applied 10 Gy in a single fraction. All rats were sacrificed on the fourth day of irradiation. Malondialdehyde (MDA), nitric oxide (NO), and glutathione (GSH) levels, myeloperoxidase (MPO), superoxide dismutase (SOD), and tissue factor activities (TFa) were determined for biochemical analysis. Hematoxylin&Eosin staining was done for histopathological analyses, and electrophoretic analyses were performed.

Results

NO, MDA, and MPO levels were higher in all irradiated groups compared with the C group. MC administration decreased NO, MDA, and MPO levels in R + preMC and R + MC groups. MC administration increased GSH levels. TFa activity decreased in R groups but did not change with MC administration compared to the C group. Radiation-induced brain tissue injury decreased, and morphologically normal neurons were observed in both MC-added groups.

Conclusion

Myrtus communis has a potential neuroprotective effect on brain tissue, attributed to its antioxidative, anti-inflammatory, and anti-lipid peroxidative properties.

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香桃木对电离辐射所致脑损伤的神经保护作用：大鼠组织病理学和生化分析的启示

方法将 30 只雌性大鼠分为 4 组。对照组（C）口服生理盐水（SF）四天。紫丁香组（MC）在照射前四天（R + preMC）或照射后四天（R + MC）立即口服 MC（100 毫克/千克）。照射剂量为单次 10 Gy。所有大鼠都在照射第四天被处死。测定丙二醛（MDA）、一氧化氮（NO）和谷胱甘肽（GSH）水平、髓过氧化物酶（MPO）、超氧化物歧化酶（SOD）和组织因子活性（TFa），以进行生化分析。结果与 C 组相比，所有辐照组的 NO、MDA 和 MPO 水平均较高。服用 MC 可降低 R + preMC 组和 R + MC 组的 NO、MDA 和 MPO 水平。服用 MC 可提高 GSH 水平。与 C 组相比，R 组的 TFa 活性降低，但 MC 给药后 TFa 活性无变化。结论香紫苏对脑组织具有潜在的神经保护作用，这归功于其抗氧化、抗炎和抗脂质过氧化的特性。

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来源期刊

Journal of Radiation Research and Applied Sciences MULTIDISCIPLINARY SCIENCES-

自引率

5.90%

发文量

130

审稿时长

16 weeks

期刊介绍： Journal of Radiation Research and Applied Sciences provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and applications of nuclear, radiation and isotopes in biology, medicine, drugs, biochemistry, microbiology, agriculture, entomology, food technology, chemistry, physics, solid states, engineering, environmental and applied sciences.

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