Clozapine induced globus pharyngeus: A case report

Psychiatry research case reports Pub Date : 2024-08-08 DOI:10.1016/j.psycr.2024.100234

Evaristus Ezema, Johnson Bamidele, Amir Meftah, Stanley Nkemjika, Bashir Aribisala, Tania Sultana, Esther Ezenagu, Singh Satwant, Thant Htet, Jude Beauchamp, Rabel Peterson, Patrice Fouron, Tolu Olupona

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Abstract

Clozapine is an atypical antipsychotic agent often recommended after the failure of two or more antipsychotics for treatment-resistant schizophrenia. Clozapine has proven efficacy in reducing morbidity and suicide in schizophrenic patients. However, it is generally underutilized for eligible patients, primarily because of the associated side effects. Notably, clozapine's side effects on the gut include hypomotility, constipation, and dysphagia, which are secondary to the anticholinergic properties of the medication. Thus far, there remains a dearth in the literature regarding reported foreign body sensations on the throat. Therefore, we report a case of foreign body sensation on the throat in a patient receiving clozapine. Foreign body sensation on the throat is an alarming concern, given the role of the oropharynx in the airway. Hence, it is imperative to evaluate unfamiliar body sensation on the throat as part of comprehensive assessment of the gut side effects of clozapine therapy.

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氯氮平诱发咽球：病例报告

氯氮平是一种非典型抗精神病药物，通常在两种或两种以上抗精神病药物治疗耐药精神分裂症失败后推荐使用。氯氮平在降低精神分裂症患者发病率和自杀率方面的疗效已得到证实。然而，对符合条件的患者来说，氯氮平的使用率普遍较低，主要原因是其相关副作用。值得注意的是，氯氮平对肠道的副作用包括蠕动减弱、便秘和吞咽困难，这些副作用是由药物的抗胆碱能特性引起的。迄今为止，有关咽喉异物感的文献报道仍然很少。因此，我们报告了一例接受氯氮平治疗的患者的咽喉异物感病例。鉴于口咽部在呼吸道中的作用，咽部异物感是一个令人担忧的问题。因此，在全面评估氯氮平治疗的肠道副作用时，有必要对咽喉异物感进行评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Psychiatry research case reports Medicine and Dentistry (General)

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