Difference in expiratory flow limitations development in normoxia and hypoxia in healthy individuals

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-14 DOI:10.1016/j.resp.2024.104316

Antoine Raberin , Giorgio Manferdelli, Forrest Schorderet, Yannick Monnier, Ruben Tato Perez, Nicolas Bourdillon, Grégoire P. Millet

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Abstract

The present study investigated the maintenance/repeatability of expiratory flow limitation (EFL) between normoxia and hypoxia.

Fifty-one healthy active individuals (27 men and 24 women) performed a lung function test and a maximal incremental cycling test in both normoxia and hypoxia (inspired oxygen fraction = 0.14) on two separate visits.

During exercise in normoxia, 28 participants exhibited EFL (55 %). In hypoxia, another cohort of 28 participants exhibited EFL. The two groups only partly overlapped.

Individuals with EFL only in normoxia reported lower maximal ventilation values in hypoxia than in normoxia (n=5; −13.5 ± 7.8 %) compared to their counterparts with EFL only in hypoxia (n=5; +6.7 ± 6.3 %) or without EFL (n=18; +5.1 ± 10.3 %) (p=0.004 and p<0.001, respectively).

EFL development may be induced by different mechanisms in hypoxia vs. normoxia since the individuals who exhibited flow limitation were not the same between the two environmental conditions. This change seems influenced by the magnitude of the maximal ventilation change.

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健康人在常氧和低氧条件下呼气流量限制发展的差异。

本研究调查了呼气流量限制（EFL）在常氧和低氧之间的维持/重复性。51 名健康的运动者（27 名男性和 24 名女性）在常氧和低氧（吸入氧分压 = 0.14）环境下分别进行了肺功能测试和最大增量骑行测试。在常氧运动中，28 名参与者表现出 EFL（55%）。在低氧状态下，另一组 28 名参与者表现出 EFL。这两组只有部分重叠。与仅在缺氧状态下有 EFL 的参与者（5 人；+6.7 ± 6.3%）或没有 EFL 的参与者（18 人；+5.1 ± 10.3%）相比，仅在常氧状态下有 EFL 的参与者在缺氧状态下的最大通气值低于常氧状态下的最大通气值（5 人；-13.5 ± 7.8%）（p=0.004 和 p=0.14）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.