The Role of Interleukin-8 in the Estimation of Responsiveness to Steps 1 and 2 of Periodontal Therapy

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2024-08-16 DOI:10.1111/jcpe.14055

Caspar Victor Bumm, Falk Schwendicke, Katrin Heck, Iris Frasheri, Burkhard Summer, Christina Ern, Richard Heym, Nils Werner, Matthias Folwaczny

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引用次数: 0

Abstract

Objective

To investigate the association between interleukin-8 (IL-8) levels in gingival crevicular fluid (GCF) and total oral fluid (TOF) and the responsiveness to steps 1 and 2 of periodontal therapy.

Materials and Methods

One-hundred and fifty-nine patients affected by periodontitis received steps 1 and 2 of periodontal therapy. At baseline, TOF and GCF samples were collected and analysed for IL-8 (Il-8_TOF/IL-8_GCF) using flow cytometry. Therapy outcomes were relative proportions of residual periodontal pockets (PPD%), pocket closure (PC) rates and pocket probing depth (PPD) reductions; these were associated with IL-8_TOF/IL-8_GCF.

Results

High IL-8_TOF was significantly associated with higher residual PPD% (p = 0.044) and lower PPD reduction compared to low IL-8_TOF (high 0.79 ± 1.20 mm vs. low 1.20 ± 1.20 mm, p < 0.001) in non-smokers, while in smokers high IL-8_GCF was related to lower PPD reduction (high 0.62 ± 1.22 mm vs. low 0.84 ± 1.12 mm, p = 0.009). Furthermore, high baseline IL-8_TOF was significantly associated with poorer PC rates compared to medium and low concentrations in both non-smokers (high 41% vs. medium 55% vs. low 58%, p < 0.001) and smokers (high 34% vs. medium 44% vs. low 46%, p < 0.001).

Conclusion

High IL-8 concentrations at baseline had a significant impact on residual PPD%, PC rates and PPD reduction. The findings suggest that, especially in non-smokers, baseline IL-8 levels collected from the TOF could serve as a component in the estimation of responsiveness to steps 1 and 2 of periodontal therapy.

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白细胞介素-8 在估计牙周治疗第一步和第二步反应中的作用

目的研究龈沟液（GCF）和总口腔液（TOF）中的白细胞介素-8（IL-8）水平与牙周治疗步骤 1 和 2 的反应性之间的关系：159名牙周炎患者接受了牙周治疗的第一步和第二步。基线时，收集 TOF 和 GCF 样本，并使用流式细胞术分析 IL-8 (Il-8TOF/IL-8GCF) 的含量。治疗结果为残留牙周袋的相对比例（PPD%）、牙周袋闭合率（PC）和牙周袋探诊深度（PPD）的减少；这些结果与IL-8TOF/IL-8GCF有关：结果：与低IL-8TOF相比，高IL-8TOF与较高的残余PPD%（p = 0.044）和较低的PPD减少率明显相关（高0.79 ± 1.20 mm vs. 低1.20 ± 1.20 mm，p GCF与较低的PPD减少率相关（高0.62 ± 1.22 mm vs. 低0.84 ± 1.12 mm，p = 0.009）。此外，与中浓度和低浓度相比，基线 IL-8TOF 高与非吸烟者较低的 PC 率显著相关（高 41% vs. 中 55% vs. 低 58%，p 结论：基线 IL-8TOF 高与非吸烟者较低的 PC 率显著相关：基线IL-8浓度高对残留PPD%、PC率和PPD减少率有显著影响。研究结果表明，特别是在非吸烟者中，从TOF中收集的基线IL-8水平可作为估计牙周治疗步骤1和步骤2反应性的一个组成部分。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.