Characteristics and causes of reported clozapine-related medication errors: analysis of the Ministry of Health database in Saudi Arabia.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

International Journal of Clinical Pharmacy Pub Date : 2024-12-01 Epub Date: 2024-08-17 DOI:10.1007/s11096-024-01782-2

Lamaa S AlAmri, Wafa S Alluwaymi, Badr G Alghamdi, Rashed A Alghanim, Afnan S Almordi, Reham F Hettah, Sahar F Almushaikah, Asma M AlShahrani, Nouf T Alshammri, Salma M Aldossari, Leena I AlAwn, Nada A Alsaleh, Ghadah H AlShehri

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引用次数: 0

Abstract

Background: Clozapine has shown great efficacy in treating treatment-resistant schizophrenia, but it is associated with a variety of medication- related safety problems. Despite this, there remains a lack of research on medication errors (MEs) associated with its use.

Aim: To characterize the nature and contributory factors of clozapine-related MEs reported from government hospitals and primary care centres in Saudi Arabia (SA).

Method: A cross-sectional analysis was carried out on MEs related to clozapine use reported to the General Administration of Pharmaceutical Care at the Ministry of Health (MOH) in Saudi Arabia between 2018 and 2022. The data were analysed descriptively to examine the nature and contributory factors of MEs.

Results: A total of 1,165 MEs were reported. The majority of reported errors involved patients aged > 18 years old, with 72.2% (n = 841) being male. The central region was found to report errors more frequently (32.3%, n = 376). Pharmacists were reported to detect errors most frequently (59.6%, n = 695). MEs most often occurred in the prescribing stage (77.8%, n = 906), with "missing prescription information" (30.1%, n = 351) being the most frequent finding. The most frequent contributing factor was the lack of policy (33.1%, n = 351). The majority of errors did not reach the patients (92.3%, n = 1,075), and those that did reach patients rarely resulted in harm (0.3%, n = 2).

Conclusion: This study identified areas for improvement which could expedite the development of remedial interventions to reduce the risk of errors.

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报告的氯氮平相关用药错误的特征和原因：沙特阿拉伯卫生部数据库分析。

背景：氯氮平在治疗难治性精神分裂症方面疗效显著，但也存在各种与用药相关的安全问题。目的：描述沙特阿拉伯（SA）政府医院和初级保健中心报告的氯氮平相关用药错误（ME）的性质和诱因：对2018年至2022年期间向沙特阿拉伯卫生部（MOH）药品护理总署报告的与氯氮平使用相关的ME进行横断面分析。对数据进行了描述性分析，以研究MEs的性质和促成因素：共报告了 1,165 例 ME。大多数报告的错误涉及年龄大于 18 岁的患者，72.2%（n = 841）为男性。中部地区报告的错误较多（32.3%，n = 376）。据报告，药剂师发现错误的频率最高（59.6%，n = 695）。ME 最常发生在处方阶段（77.8%，n = 906），其中 "处方信息缺失"（30.1%，n = 351）是最常见的发现。最常见的诱因是缺乏政策（33.1%，n = 351）。大多数错误没有影响到患者（92.3%，n = 1,075），影响到患者的错误很少造成伤害（0.3%，n = 2）：这项研究确定了需要改进的领域，可加快制定补救措施，降低出错风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Pharmacy PHARMACOLOGY & PHARMACY-

CiteScore

4.10

自引率

8.30%

发文量

131

审稿时长

4-8 weeks

期刊介绍： The International Journal of Clinical Pharmacy (IJCP) offers a platform for articles on research in Clinical Pharmacy, Pharmaceutical Care and related practice-oriented subjects in the pharmaceutical sciences. IJCP is a bi-monthly, international, peer-reviewed journal that publishes original research data, new ideas and discussions on pharmacotherapy and outcome research, clinical pharmacy, pharmacoepidemiology, pharmacoeconomics, the clinical use of medicines, medical devices and laboratory tests, information on medicines and medical devices information, pharmacy services research, medication management, other clinical aspects of pharmacy. IJCP publishes original Research articles, Review articles , Short research reports, Commentaries, book reviews, and Letters to the Editor. International Journal of Clinical Pharmacy is affiliated with the European Society of Clinical Pharmacy (ESCP). ESCP promotes practice and research in Clinical Pharmacy, especially in Europe. The general aim of the society is to advance education, practice and research in Clinical Pharmacy . Until 2010 the journal was called Pharmacy World & Science.