Real-world outcomes of long-term use of silexan in patients with anxiety disorders: a single-centre experience.

IF 2.9 4区医学 Q2 PSYCHIATRY

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-08-18 DOI:10.1080/13651501.2024.2391301

Sergio Marchevsky

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引用次数: 0

Abstract

Objective: To evaluate the effectiveness and safety of long-term use of silexan in patients with a wide range of anxiety disorders.

Methods: A retrospective chart review was conducted on 50 patients diagnosed with various anxiety disorders who were prescribed silexan. The primary outcomes measured included the resolution of anxiety symptoms, changes in Generalized Anxiety Disorder-7 (GAD-7) scores, and Clinical Global Impressions-Improvement (CGI-I) scores. The duration of silexan use and any reported adverse events were also recorded.

Results: Silexan effectively resolved anxiety symptoms in 35 patients, with 24 out of 25 patients who received silexan for more than 12 weeks showing significant improvement. Median GAD-7 and CGI-I scores decreased significantly (p<0.001). By the end of the follow-up period, 46% of patients had minimal anxiety and 24% had mild anxiety. No adverse events were reported during the study period.

Conclusions: Long-term use of silexan is feasible, safe, and effective in managing a wide range of anxiety disorders in real-world clinical settings.

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焦虑症患者长期服用西乐葆的实际效果：单中心经验。

目的：评估长期服用西乐葆对各种焦虑症患者的有效性和安全性：评估长期服用西乐葆对各种焦虑症患者的有效性和安全性：方法：对 50 名被诊断患有各种焦虑症并被处方施利欣的患者进行回顾性病历审查。测量的主要结果包括焦虑症状的缓解、广泛性焦虑症-7（GAD-7）评分的变化以及临床总体印象-改善（CGI-I）评分。此外，还记录了西乐葆的使用时间和报告的不良事件：结果：西力生有效缓解了35名患者的焦虑症状，在接受西力生治疗超过12周的25名患者中，有24名患者的焦虑症状得到了明显改善。GAD-7和CGI-I评分的中位数明显降低（p结论：长期服用西乐葆可有效缓解焦虑症状：在现实世界的临床环境中，长期使用西力生治疗各种焦虑症是可行、安全和有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Psychiatry in Clinical Practice 医学-精神病学

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： International Journal of Psychiatry in Clinical Practice provides an international forum for communication among health professionals with clinical, academic and research interests in psychiatry. The journal gives particular emphasis to papers that integrate the findings of academic research into realities of clinical practice. Focus on the practical aspects of managing and treating patients. Essential reading for the busy psychiatrist, trainee and interested physician. Includes original research papers, comprehensive review articles and short communications. Key words: Psychiatry, Neuropsychopharmacology, Mental health, Neuropsychiatry, Clinical Neurophysiology, Psychophysiology, Psychotherapy, Addiction, Schizophrenia, Depression, Bipolar Disorders and Anxiety.