{"title":"Simple and effective: Superlubricity behaviour of the G-quadruplex hydrogel with high selectivity for K+ ions based on the ocular environment","authors":"Hongdong Wang, Jian Wu, Kunpeng Wang, Yunjuan Su, Xiacong Zhang, Yuhong Liu, Jianhua Zhang","doi":"10.1007/s40544-024-0898-z","DOIUrl":null,"url":null,"abstract":"<p>Hydrogels have been the subject of significant research in the field of friction due to their exceptional lubricating properties. In this study, the G-quadruplex hydrogel with high selectivity for K<sup>+</sup> ions was formed by introducing a mixture of G, 2-formylphenylboronic acid, and polyethylene glycol diamine into simulated artificial tears solution with high transparency, and an ultra-low coefficient of friction (COF) of about 0.004 was obtained based on the simulated ocular environment, thus achieving macroscopic superlubricity. In friction pairs simulating the ocular environment, to assess the frictional performance of the G-quadruplex hydrogel as both a lubricant and a friction pair based on the simulated ocular environment, we conducted experiments considering various factors such as concentration, sliding speed, and stress. Through these experiments, it was found that superlubricity was achieved when the G-quadruplex hydrogel was applied as lubricant or friction pair. This effect was attributed to the three-dimensional network structure and hydrophilicity of the hydrogel, which facilitated the formation of a highly bearing and flowing hydration layer, promoting macroscopic superlubricity. Compared to the G-quadruplex hydrogel with low concentration, the high concentration hydrogel (75 mM) exhibited increased mechanical strength and robustness in superlubricity. Combined with biocompatibility experiments, our synthesized G-quadruplex hydrogel has excellent biocompatibility and offers a novel approach to achieve superlubricity in ocular drug delivery.</p>","PeriodicalId":12442,"journal":{"name":"Friction","volume":"6 1","pages":""},"PeriodicalIF":6.3000,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Friction","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s40544-024-0898-z","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MECHANICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Hydrogels have been the subject of significant research in the field of friction due to their exceptional lubricating properties. In this study, the G-quadruplex hydrogel with high selectivity for K+ ions was formed by introducing a mixture of G, 2-formylphenylboronic acid, and polyethylene glycol diamine into simulated artificial tears solution with high transparency, and an ultra-low coefficient of friction (COF) of about 0.004 was obtained based on the simulated ocular environment, thus achieving macroscopic superlubricity. In friction pairs simulating the ocular environment, to assess the frictional performance of the G-quadruplex hydrogel as both a lubricant and a friction pair based on the simulated ocular environment, we conducted experiments considering various factors such as concentration, sliding speed, and stress. Through these experiments, it was found that superlubricity was achieved when the G-quadruplex hydrogel was applied as lubricant or friction pair. This effect was attributed to the three-dimensional network structure and hydrophilicity of the hydrogel, which facilitated the formation of a highly bearing and flowing hydration layer, promoting macroscopic superlubricity. Compared to the G-quadruplex hydrogel with low concentration, the high concentration hydrogel (75 mM) exhibited increased mechanical strength and robustness in superlubricity. Combined with biocompatibility experiments, our synthesized G-quadruplex hydrogel has excellent biocompatibility and offers a novel approach to achieve superlubricity in ocular drug delivery.
期刊介绍:
Friction is a peer-reviewed international journal for the publication of theoretical and experimental research works related to the friction, lubrication and wear. Original, high quality research papers and review articles on all aspects of tribology are welcome, including, but are not limited to, a variety of topics, such as:
Friction: Origin of friction, Friction theories, New phenomena of friction, Nano-friction, Ultra-low friction, Molecular friction, Ultra-high friction, Friction at high speed, Friction at high temperature or low temperature, Friction at solid/liquid interfaces, Bio-friction, Adhesion, etc.
Lubrication: Superlubricity, Green lubricants, Nano-lubrication, Boundary lubrication, Thin film lubrication, Elastohydrodynamic lubrication, Mixed lubrication, New lubricants, New additives, Gas lubrication, Solid lubrication, etc.
Wear: Wear materials, Wear mechanism, Wear models, Wear in severe conditions, Wear measurement, Wear monitoring, etc.
Surface Engineering: Surface texturing, Molecular films, Surface coatings, Surface modification, Bionic surfaces, etc.
Basic Sciences: Tribology system, Principles of tribology, Thermodynamics of tribo-systems, Micro-fluidics, Thermal stability of tribo-systems, etc.
Friction is an open access journal. It is published quarterly by Tsinghua University Press and Springer, and sponsored by the State Key Laboratory of Tribology (TsinghuaUniversity) and the Tribology Institute of Chinese Mechanical Engineering Society.