A portable photoacoustic microscopy and ultrasound system for rectal cancer imaging

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics Pub Date : 2024-08-14 DOI:10.1016/j.pacs.2024.100640

Sitai Kou , Sanskar Thakur , Ahmed Eltahir , Haolin Nie , Yitian Zhang , Andrew Song , Steven R. Hunt , Matthew G. Mutch , William C. Chapman Jr , Quing Zhu

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引用次数: 0

Abstract

Photoacoustic microscopy offers functional information regarding tissue vasculature while ultrasound characterizes tissue structure. Combining these two modalities provides novel clinical applications including response assessment among rectal cancer patients undergoing therapy. We have previously demonstrated the capabilities of a co-registered photoacoustic and ultrasound device in vivo, but multiple challenges limited broad adoption. In this paper, we report significant improvements in an acoustic resolution photoacoustic microscopy and ultrasound (ARPAM/US) system characterized by simulation and phantom study, focusing on resolution, optical coupling, and signal characteristics. In turn, higher in-probe optical coupling efficiency, higher signal-to-noise ratio, higher data throughput, and better stability with minimal maintenance requirements were all accomplished. We applied the system to 19 ex vivo resected colorectal cancer samples and found significantly different signals between normal, cancer, and post-treatment tumor tissues. Finally, we report initial results of the first in vivo imaging study.

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用于直肠癌成像的便携式光声显微镜和超声系统

光声显微镜提供有关组织血管的功能信息，而超声波则描述组织结构。这两种模式的结合提供了新颖的临床应用，包括对接受治疗的直肠癌患者进行反应评估。我们之前已在体内展示了光声和超声共注册设备的功能，但多种挑战限制了其广泛应用。在本文中，我们报告了声学分辨光声显微镜和超声（ARPAM/US）系统的重大改进，通过模拟和模型研究，重点关注分辨力、光学耦合和信号特征。反过来，探头内光学耦合效率更高、信噪比更高、数据吞吐量更大、稳定性更好且维护要求最低。我们将该系统应用于 19 个切除的体外结直肠癌样本，发现正常组织、癌症组织和治疗后的肿瘤组织之间的信号存在明显差异。最后，我们报告了首次体内成像研究的初步结果。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.