Reduced plasma interleukin-6 concentration after transcranial direct current stimulation to the prefrontal cortex

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2024-08-14 DOI:10.1016/j.bbr.2024.115201

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引用次数: 0

Abstract

Objectives

Transcranial direct stimulation (tDCS) targeted to the dorsolateral prefrontal cortex (DLPFC) reduces food intake and hunger, but its effects on circulating factors are unclear. We assessed the effect of repeated administration of tDCS to the left DLPFC (L-DLPFC) on concentrations of pro/anti-inflammatory and appetitive hormone concentrations.

Materials and methods

Twenty-nine healthy adults with obesity (12 M; 42±11 y; BMI=39±8 kg/m²) received 3 consecutive inpatient sessions of either anodal or sham tDCS targeted to the L-DLPFC during a period of ad libitum food intake. Fasting plasma concentrations of IL-6, orexin, cortisol, TNF-α, IL-1β, ghrelin, PYY, and GLP-1 were measured before the initial and after the final tDCS sessions.

Results

IL-6 (β=-0.92 pg/ml p=0.03) decreased in the anodal group compared with sham, even after adjusting for kcal intake; there were no changes in other hormones. Mean kcal intake was associated with higher IL-1β and ghrelin concentrations after the ad libitum period (β=0.00018 pg/ml/kcal, p=0.03; β=0.00011 pg/ml/kcal, p=0.02; respectively), but not differ by intervention groups.

Conclusions

IL-6 concentrations were reduced following anodal tDCS to the L-DLPFC independent of ad libitum intake. IL-6 concentrations reflect the inflammatory state of adiposity and may affect eating behavior and weight gain. These findings provide evidence of therapeutic benefit of tDCS.

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经颅直流电刺激前额叶皮层后血浆白细胞介素-6浓度降低

目的针对背外侧前额叶皮层（DLPFC）的经颅直接刺激（tDCS）可减少食物摄入量和饥饿感，但其对循环因素的影响尚不清楚。我们评估了对左侧DLPFC（L-DLPFC）重复施用tDCS对促炎/抗炎激素和食欲激素浓度的影响。材料与方法29名健康的肥胖成人（12名男性；42±11岁；BMI=39±8 kg/m2）在自由摄入食物期间接受了连续3次针对L-DLPFC的阳极或假tDCS住院治疗。结果 IL-6 (β=-0.92 pg/ml p=0.03)在阳极组比假体组降低，即使在调整了千卡摄入量后也是如此；其他激素没有变化。平均千卡摄入量与ad libitum期后较高的IL-1β和ghrelin浓度有关（β=0.00018 pg/ml/kcal，p=0.03；β=0.00011 pg/ml/kcal，p=0.02；分别为0.00011 pg/ml/kcal，p=0.02；），但干预组之间没有差异。IL-6浓度反映了脂肪的炎症状态，并可能影响进食行为和体重增加。这些发现为 tDCS 的治疗效果提供了证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.