Determination of systemic inflammation response index (SIRI), systemic inflammatory index (SII), HMGB1, Mx1 and TNF levels in neonatal calf diarrhea with systemic inflammatory response syndrome

IF 1.4 3区农林科学 Q4 IMMUNOLOGY

Veterinary immunology and immunopathology Pub Date : 2024-08-12 DOI:10.1016/j.vetimm.2024.110815

Ömer Aydın , Betül Apaydın Yıldırım

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引用次数: 0

Abstract

The objective of this study was to examine the values of MX dynamin-like GTPase 1 (Mx1), high mobility group box-1 (HMGB1), systemic inflammatory response index (SIRI), systemic inflammatory index (SII), tumor necrosis factor (TNF), and other hematological indices in calves with systemic inflammatory response syndrome (SIRS). The study material was divided into two groups: the SIRS group (comprising 13 calves) and the control group (comprising 10 calves). The independent samples t-test and Mann-Whitney U test were employed for normally distributed and non-normally distributed data, respectively. The relationship between the two groups was determined using Spearman correlation coefficient analysis. Significant differences were identified between the SIRS group and the control group with regard to white blood cell (WBC; P < 0.05), neutrophil (NEU; P < 0.01), and neutrophil-to-lymphocyte ratio (NLR; P < 0.001) values, in addition to SIRI (P < 0.05), SII (P < 0.01) values. Furthermore, HMGB1 (P < 0.001), Mx1 (P < 0.05), and TNF values (P < 0.001) demonstrated notable disparities between the two groups. As a result of this study, it was concluded that there were significant increases in inflammatory hematological indices, as well as in the levels of HMGB1, Mx1, and TNF, in calves with SIRS.

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测定新生犊牛腹泻伴全身炎症反应综合征的全身炎症反应指数（SIRI）、全身炎症指数（SII）、HMGB1、Mx1 和 TNF 水平

本研究的目的是检测全身炎症反应综合征（SIRS）犊牛体内MX达纳明样GTP酶1（Mx1）、高迁移率组盒-1（HMGB1）、全身炎症反应指数（SIRI）、全身炎症指数（SII）、肿瘤坏死因子（TNF）和其他血液学指标的数值。研究材料分为两组：SIRS 组（13 头犊牛）和对照组（10 头犊牛）。对正态分布和非正态分布数据分别采用独立样本 t 检验和曼-惠特尼 U 检验。采用斯皮尔曼相关系数分析确定两组之间的关系。结果发现，SIRS 组与对照组在白细胞（WBC；P <；0.05）、中性粒细胞（NEU；P <；0.01）、中性粒细胞与淋巴细胞比值（NLR；P <；0.001）以及 SIRI（P <；0.05）、SII（P <；0.01）值方面存在显著差异。此外，两组患者的 HMGB1（P <0.001）、Mx1（P <0.05）和 TNF 值（P <0.001）也存在明显差异。本研究的结论是，患有 SIRS 的犊牛的炎症性血液指数以及 HMGB1、Mx1 和 TNF 水平均显著增加。

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来源期刊

Veterinary immunology and immunopathology 农林科学-免疫学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

70 days

期刊介绍： The journal reports basic, comparative and clinical immunology as they pertain to the animal species designated here: livestock, poultry, and fish species that are major food animals and companion animals such as cats, dogs, horses and camels, and wildlife species that act as reservoirs for food, companion or human infectious diseases, or as models for human disease. Rodent models of infectious diseases that are of importance in the animal species indicated above,when the disease requires a level of containment that is not readily available for larger animal experimentation (ABSL3), will be considered. Papers on rabbits, lizards, guinea pigs, badgers, armadillos, elephants, antelope, and buffalo will be reviewed if the research advances our fundamental understanding of immunology, or if they act as a reservoir of infectious disease for the primary animal species designated above, or for humans. Manuscripts employing other species will be reviewed if justified as fitting into the categories above. The following topics are appropriate: biology of cells and mechanisms of the immune system, immunochemistry, immunodeficiencies, immunodiagnosis, immunogenetics, immunopathology, immunology of infectious disease and tumors, immunoprophylaxis including vaccine development and delivery, immunological aspects of pregnancy including passive immunity, autoimmuity, neuroimmunology, and transplanatation immunology. Manuscripts that describe new genes and development of tools such as monoclonal antibodies are also of interest when part of a larger biological study. Studies employing extracts or constituents (plant extracts, feed additives or microbiome) must be sufficiently defined to be reproduced in other laboratories and also provide evidence for possible mechanisms and not simply show an effect on the immune system.