Stimuli-Responsive Polymers for Advanced ¹⁹F Magnetic Resonance Imaging: From Chemical Design to Biomedical Applications.

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2024-09-09 Epub Date: 2024-08-16 DOI:10.1021/acs.biomac.4c00833

Tuba Ayça Tunca Arın, Ondrej Sedlacek

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Abstract

Fluorine magnetic resonance imaging (¹⁹F MRI) is a rapidly evolving research area with a high potential to advance the field of clinical diagnostics. In this review, we provide an overview of the recent progress in the field of fluorinated stimuli-responsive polymers applied as ¹⁹F MRI tracers. These polymers respond to internal or external stimuli (e.g., temperature, pH, oxidative stress, and specific molecules) by altering their physicochemical properties, such as self-assembly, drug release, and polymer degradation. Incorporating noninvasive ¹⁹F labels enables us to track the biodistribution of such polymers. Furthermore, by triggering polymer transformation, we can induce changes in ¹⁹F MRI signals, including attenuation, amplification, and chemical shift changes, to monitor alterations in the environment of the tracer. Ultimately, this review highlights the emerging potential of stimuli-responsive fluoropolymer ¹⁹F MRI tracers in the current context of polymer diagnostics research.

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用于先进 19F 磁共振成像的刺激响应聚合物：从化学设计到生物医学应用。

氟磁共振成像（19F MRI）是一个发展迅速的研究领域，具有推动临床诊断领域发展的巨大潜力。在本综述中，我们将概述作为 19F 磁共振成像示踪剂的含氟刺激响应聚合物领域的最新进展。这些聚合物通过改变其物理化学特性（如自组装、药物释放和聚合物降解）来对内部或外部刺激（如温度、pH 值、氧化应激和特定分子）做出反应。加入非侵入性的 19F 标签使我们能够跟踪此类聚合物的生物分布。此外，通过触发聚合物转化，我们可以诱导 19F MRI 信号发生变化，包括衰减、放大和化学位移变化，从而监测示踪剂环境的改变。最后，本综述强调了刺激响应型含氟聚合物 19F MRI 示踪剂在当前聚合物诊断研究中的新兴潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.