Artificial boron enzymes

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2024-08-16 DOI:10.1038/s41589-024-01707-0

Xiao-Wang Chen, Zhiyu Bo, Yang Yang

引用次数: 0

Abstract

Boron is a common element found in various minerals; however, it is not used in life-creating machinery in nature. In a new study, boron enzymes have been created by introducing a boronic acid-containing non-canonical amino acid into an artificial enzyme scaffold. Further development via directed evolution enabled the selection of new-to-nature stereoselective chemistry.

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人工硼酶

硼是存在于各种矿物质中的一种常见元素，但它在自然界中并没有被用于创造生命的机器中。在一项新的研究中，通过在人工酶支架中引入一种含有硼酸的非经典氨基酸，创造出了硼酶。通过定向进化的进一步发展，选择了新的自然立体选择性化学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.