Effects of continuous negative pressure suction combined with autologous platelet-rich gel on the levels of CRP, IL-6, wound healing and length of stay in clients with diabetic foot

IF 1.4 4区医学 Q4 HEMATOLOGY

Transfusion and Apheresis Science Pub Date : 2024-08-10 DOI:10.1016/j.transci.2024.103989

Lan Zhang , Yuan Zhao , Xiaoyun Fan, Dongliang Liu, Yan Geng

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Abstract

Objective

Continuous passive pressure suction and APG gel therapy effect diabetic foot IL-6, CRP, wound healing, and hospitalization.

Methods

Clinicopathological data from 102 diabetic foot ulcer patients treated at our institution between March 2018 and May 2022 was examined. Tables generated 51 joint and controlling teams randomly. The observation team received passive pressure suction and APG gel whereas the controlled team received conventional treatment. Teams monitored therapy outcomes, adverse responses, wound healing, hospital stay, and costs. Both teams compared blood uric acid, cystatin C, homocysteine, and serum IL-6, IL-10, and CRP before and after medication.

Results

The joint team had higher hospitalization costs, shorter stays, and faster wound healing than the controlled team. Diaparity was significant (P < 0.05). The united team worked 100 %, unlike the controlling team. This difference was significant (P < 0.05). Both teams showed significant decreases in CRP, IL-6, and IL-10 levels after therapy (P < 0.05). After therapy, both the combined and controlled teams had substantial differences in blood CRP, IL-6, and IL-10 levels (P < 0.05). Both teams had significantly decreased uric acid, cystatin C, and homocysteine after treatment. The combined team showed significantly decreased uric acid, cystatin C, homocysteine levels following therapy compared to the control team (P < 0.05).

Conclusion

The joint team experienced considerably fewer adverse events (3.92 % vs. 17.65 %) than the controls team (P < 0.05). Permanent passive pressure suction and APG gel therapy lower inflammatory response, blood uric acid, cystatin C, and homocysteine, speeding wound healing, reducing side effects.

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持续负压吸引结合自体血小板丰富凝胶对糖尿病足患者 CRP、IL-6 水平、伤口愈合和住院时间的影响

目的连续被动压力吸引和APG凝胶治疗对糖尿病足IL-6、CRP、伤口愈合和住院治疗的影响。方法对2018年3月至2022年5月期间在我院接受治疗的102例糖尿病足溃疡患者的临床病理资料进行研究。表格随机生成51个联合组和对照组。观察组接受被动压力吸引和 APG 凝胶治疗，对照组接受常规治疗。各小组对治疗结果、不良反应、伤口愈合、住院时间和费用进行监测。两个小组比较了用药前后的血尿酸、胱抑素 C、同型半胱氨酸以及血清 IL-6、IL-10 和 CRP。差异显著（P < 0.05）。与对照组不同，联合小组的工作效率为 100%。这一差异非常明显（P < 0.05）。治疗后，两个团队的 CRP、IL-6 和 IL-10 水平都有明显下降（P < 0.05）。治疗后，联合组和对照组的血液 CRP、IL-6 和 IL-10 水平都有很大差异（P < 0.05）。治疗后，两组的尿酸、胱抑素 C 和同型半胱氨酸均明显下降。与对照组相比，联合治疗组治疗后尿酸、胱抑素 C 和同型半胱氨酸水平明显下降（P < 0.05）。永久性被动压力吸引和 APG 凝胶疗法可降低炎症反应、血尿酸、胱抑素 C 和同型半胱氨酸，加快伤口愈合，减少副作用。

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来源期刊

Transfusion and Apheresis Science 医学-血液学

CiteScore

3.60

自引率

5.30%

发文量

181

审稿时长

42 days

期刊介绍： Transfusion and Apheresis Science brings comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of transfusion medicine, hemostasis and apheresis. The journal presents original articles relating to scientific and clinical studies in the areas of immunohematology, transfusion practice, bleeding and thrombotic disorders and both therapeutic and donor apheresis including hematopoietic stem cells. Topics covered include the collection and processing of blood, compatibility testing and guidelines for the use of blood products, as well as screening for and transmission of blood-borne diseases. All areas of apheresis - therapeutic and collection - are also addressed. We would like to specifically encourage allied health professionals in this area to submit manuscripts that relate to improved patient and donor care, technical aspects and educational issues. Transfusion and Apheresis Science features a "Theme" section which includes, in each issue, a group of papers designed to review a specific topic of current importance in transfusion and hemostasis for the discussion of topical issues specific to apheresis and focuses on the operators'' viewpoint. Another section is "What''s Happening" which provides informal reporting of activities in the field. In addition, brief case reports and Letters to the Editor, as well as reviews of meetings and events of general interest, and a listing of recent patents make the journal a complete source of information for practitioners of transfusion, hemostasis and apheresis science. Immediate dissemination of important information is ensured by the commitment of Transfusion and Apheresis Science to rapid publication of both symposia and submitted papers.