Construction of 2-Substituted-3-aryl Benzofurans and Indoles through an Acid-Catalyzed Cascade Intramolecular Friedel-Crafts Reaction/Rearrangement/Aromatization Process

Abstract

We present here a new method for the synthesis of 2-substituted-3-aryl benzoheterocycles through a more challenging constrained [1,5]-type Friedel–Crafts reaction/rearrangement and aromatization process. By using the readily available 2-aryoxy-1,3-indandiones and 2-arylamino-1,3-indandiones, a range of 2-substituted-3-aryl benzofurans and indoles were prepared in good to excellent yields (yields up to 86%) under the catalysis of CF₃SO₃H or Sm(OTf)₃. Compared with previous methods for constructing similar structures, this approach offers several advantages, including the use of easily accessible starting materials, mild reaction conditions, high yield, excellent regio- and diastereoselectivity, and a broad substrate scope.