On-Demand Production of Two Commercial Plant Activators, Tiadinil and Methiadinil, under an Integrated Continuous Flow System

IF 3.5 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2024-07-21 DOI:10.1021/acs.oprd.4c0004310.1021/acs.oprd.4c00043

Zhengqi Fang, Jian Zhou, Dong Xing, Haibing He* and Shuanhu Gao*,

引用次数: 0

Abstract

A continuous synthesis of two plant activators, tiadinil and methiadinil, was developed by using reaction chips. After exploring the synthetic approach in batch at the first stage, the key intermediate 4-methyl-1,2,3-thiadiazole-5-carboxylic acid was prepared in 70% yield by using a hybrid device equipped with two reaction chips. Tiadinil and methiadinil were then obtained in 88 and 81% yields, respectively, through a quick condensation reaction (81 s) in a reaction chip. This study showcases the potential of continuous flow chemistry in the field of agricultural and fine chemicals.

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在集成连续流系统下按需生产两种商用植物活化剂--噻菌胺和甲噻菌胺

利用反应芯片开发了一种连续合成噻二嘧啶和甲噻二嘧啶这两种植物活化剂的方法。在第一阶段探索了批量合成方法后，利用配备两个反应芯片的混合装置制备了关键中间体 4-甲基-1,2,3-噻二唑-5-羧酸，收率为 70%。然后，通过在一个反应芯片中进行快速缩合反应（81 秒），分别以 88% 和 81% 的收率获得了噻二嘧啶和甲噻二嘧啶。这项研究展示了连续流化学在农用化学品和精细化学品领域的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.