Analysis of Intestinal Microbiota in Schizophrenic Patients with Type 2 Diabetes Mellitus.

IF 1.3 Q3 PSYCHIATRY

Alpha psychiatry Pub Date : 2024-06-01 DOI:10.5152/alphapsychiatry.2024.231302

Nan Wang, Chunlei Yin, Ruiqi Feng, Rong Jia, Liguo Zhou, Wenyu Wu, Haiyan Yu, Yuan Ye, Zhiting Gong, Lijuan Li

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Abstract

Objective: Our goal is to examine the correlation between gut microbiota and the cooccurrence of schizophrenia and type 2 diabetes.

Methods: We conducted a study on the intestinal microbiota of 4 distinct groups: simple schizophrenia group (SC), schizophrenia with type 2 diabetes group (TS), type 2 diabetes group (T2DM), and normal population control group (HC), comprising a total of 35 subjects.

Results: The bacteria phyla Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and Verrucobacteria were consistently present across all 4 groups. Significantly higher intestinal microbiota richness was observed in the T2DM compared to the other group, and the intestinal microbiota richness in TS significantly lower than that of the SC.

Conclusion: Our study suggests that the presence of type 2 diabetes in individuals with schizophrenia may affect the composition of their gut microbiota. We hypothesize that the concurrent existence of both diseases could potentially lead to alterations in the structure of gut microbiota, potentially influencing treatment effectiveness and outcomes.

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分析患有 2 型糖尿病的精神分裂症患者的肠道微生物群。

目的：我们的目标是研究肠道微生物群与精神分裂症和 2 型糖尿病并发之间的相关性：我们的目标是研究肠道微生物群与精神分裂症和 2 型糖尿病并发症之间的相关性：我们对4个不同组别（单纯精神分裂症组（SC）、精神分裂症合并2型糖尿病组（TS）、2型糖尿病组（T2DM）和正常人群对照组（HC），共35名受试者）的肠道微生物群进行了研究：结果：在所有 4 个组别中，固缩菌门、类杆菌门、变形菌门、放线菌门和疣状杆菌门都一致存在。T2DM组的肠道微生物群丰富度明显高于其他组，而TS组的肠道微生物群丰富度明显低于SC组：我们的研究表明，精神分裂症患者患有 2 型糖尿病可能会影响其肠道微生物群的组成。我们假设，同时患有这两种疾病可能会导致肠道微生物群结构的改变，从而影响治疗效果和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Alpha psychiatry

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