Correlations between blood vessel distribution, lung function and structural change in idiopathic pulmonary fibrosis.

IF 6.6 2区医学 Q1 RESPIRATORY SYSTEM

Respirology Pub Date : 2024-08-15 DOI:10.1111/resp.14811

Po-Wei Hu, Chun-Ku Chen, Yi-Han Hsiao, Ching-Yao Weng, Ying-Chi Lee, Kang-Cheng Su, Jia-Yih Feng, Kun-Ta Chou, Diahn-Warng Perng, Hsin-Kuo Ko

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Abstract

Background and objective: Correlations between the image analysis of CT scan, lung function and quality of life in patients with idiopathic pulmonary fibrosis (IPF) remain unclear. This study aimed to investigate the impacts of pulmonary blood-vessel distribution and the extent of fibrosis on the lung function and quality of life of patients with IPF.

Methods: Patients were enrolled in an IPF registry and had completed pulmonary function tests, chest HRCT, St. George Respiratory Questionnaire (SGRQ) and echocardiography. Pulmonary blood-vessel distribution, specific image-derived airway volume (siVaw) and fibrosis extent (siVfib) were quantitatively calculated by functional respiratory imaging on HRCT.

Results: The study subjects were categorized into DLco <40% pred. (n = 40) and DLco ≥40% pred. (n = 19) groups. Patients with DLco <40% pred. had significantly higher scores of SGRQ, composite physiologic index (CPI), exercise oxygen desaturation (∆SpO₂), siVaw, lower FVC% pred. and 6-minute walking distance% pred. The proportion of small blood vessels in the upper lobes (BV5PR-UL) was significantly correlated with CPI, DLco % Pred., FVC% pred., SGRQ and ∆SpO₂. Only BV5PR-UL had a significant impact on all indices but not BV5PR in the lower lobes (BV5PR-LL). siVfib was significantly negatively correlated with BV5PR-UL, DLco% pred. and FVC% pred., as well as positively correlated with CPI, ∆SpO₂ and siVaw.

Conclusion: BV5PR-UL and siVfib had significant correlations with lung function and may become important indicators to assess the severity of IPF and the impact on quality of life.

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特发性肺纤维化中血管分布、肺功能和结构变化之间的相关性。

背景和目的：特发性肺纤维化（IPF）患者CT扫描图像分析、肺功能和生活质量之间的相关性仍不明确。本研究旨在探讨肺血管分布和纤维化程度对特发性肺纤维化患者肺功能和生活质量的影响：方法：IPF 登记患者均已完成肺功能测试、胸部 HRCT、圣乔治呼吸问卷 (SGRQ) 和超声心动图检查。通过 HRCT 功能性呼吸成像定量计算肺血管分布、特定图像衍生气道容积（siVaw）和纤维化程度（siVfib）：研究对象被分为 DLco 2）、siVaw、较低的 FVC% pred.和 6 分钟步行距离% pred.。上叶小血管比例（BV5PR-UL）与 CPI、DLco 预测值%、FVC 预测值%、SGRQ 和 ∆SpO2 显著相关。siVfib 与 BV5PR-UL、DLco% 预测值和 FVC% 预测值呈显著负相关，与 CPI、ΔSpO2 和 siVaw 呈显著正相关：结论：BV5PR-UL 和 siVfib 与肺功能有明显相关性，可能成为评估 IPF 严重程度和对生活质量影响的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respirology 医学-呼吸系统

CiteScore

10.60

自引率

5.80%

发文量

225

审稿时长

1 months

期刊介绍： Respirology is a journal of international standing, publishing peer-reviewed articles of scientific excellence in clinical and clinically-relevant experimental respiratory biology and disease. Fields of research include immunology, intensive and critical care, epidemiology, cell and molecular biology, pathology, pharmacology, physiology, paediatric respiratory medicine, clinical trials, interventional pulmonology and thoracic surgery. The Journal aims to encourage the international exchange of results and publishes papers in the following categories: Original Articles, Editorials, Reviews, and Correspondences. Respirology is the preferred journal of the Thoracic Society of Australia and New Zealand, has been adopted as the preferred English journal of the Japanese Respiratory Society and the Taiwan Society of Pulmonary and Critical Care Medicine and is an official journal of the World Association for Bronchology and Interventional Pulmonology.