Patterns of migraine medication use in Norway: A nationwide registry-based observational study.

IF 5 2区 医学 Q1 CLINICAL NEUROLOGY
Anker Stubberud, Solveig Borkenhagen, Francisco Oteiza, Aud Nome Dueland, Christoffer Bugge, Erik Magnus Sæther, Erling Tronvik, Lars Jacob Stovner, Marte-Helene Bjørk
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Abstract

Objective: The objective of this study was to describe and discuss patterns of migraine medication use in the entire Norwegian population.

Methods: In this nationwide, observational study, all individuals with a migraine-related prescription between 2010 and 2020 were identified using the Norwegian Prescription Database. The outcomes of interest were the incidence and 1-year prevalence of migraine medication users, as well as individuals with triptan overuse. Patterns of medication use were statistically compared between women and men adjusted for age, year of treatment start, comorbidities and county of residence calculating adjusted odds ratios (aOR) with 95% confidence intervals (CI).

Results: We identified 327,904 migraine medication users. The incidence ranged from 0.39% to 0.46%, and the 1-year prevalence increased from 1.99% to 2.99%. Preventive use increased >50% during the study period. Preventives were significantly more often prescribed to women than to men (39.72% vs. 33.75%; aOR 1.41, 95% CI 1.38 to 1.44). Triptan overuse was significantly more common among women, but women with overuse were more often using preventives, as compared to men (56.64% vs 52.69%; aOR = 1.43, 95% CI 1.37 to 1.49).

Conclusion: The prevalence of medically treated migraine is low. Overuse of triptans is frequent, especially among women. Clinicians should be encouraged to try out different triptans, recognize triptan overuse, and prescribe preventives when indicated.

挪威偏头痛用药模式:一项基于全国登记册的观察研究。
研究目的本研究旨在描述和讨论挪威全国人口偏头痛的用药模式:在这项全国范围的观察性研究中,利用挪威处方数据库对2010年至2020年间开具偏头痛相关处方的所有个人进行了识别。研究结果包括偏头痛患者的发病率和1年患病率,以及过度使用三苯氧胺的人数。根据年龄、开始治疗的年份、合并症和居住地的郡县,计算调整后的几率比(aOR)和95%置信区间(CI),对女性和男性的用药模式进行统计比较:我们确定了 327 904 名偏头痛药物使用者。发病率从 0.39% 到 0.46%,1 年患病率从 1.99% 上升到 2.99%。在研究期间,预防性用药增加了50%以上。女性处方预防药物的比例明显高于男性(39.72% 对 33.75%;aOR 1.41,95% CI 1.38 至 1.44)。与男性相比(56.64% vs 52.69%;aOR = 1.43,95% CI 1.37 to 1.49),女性更常过度使用曲普坦,但过度使用的女性更常使用预防性药物:结论:通过药物治疗偏头痛的发病率较低。结论:接受药物治疗的偏头痛发病率较低,经常出现过度使用三苯氧胺的情况,尤其是女性。应鼓励临床医生尝试不同的三苯氧胺类药物,识别三苯氧胺类药物的过度使用,并在必要时开具预防处方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cephalalgia
Cephalalgia 医学-临床神经学
CiteScore
10.10
自引率
6.10%
发文量
108
审稿时长
4-8 weeks
期刊介绍: Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.
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