Light-Activated Virtual Sensor Array with Machine Learning for Non-Invasive Diagnosis of Coronary Heart Disease

IF 26.6 1区材料科学 Q1 Engineering

Nano-Micro Letters Pub Date : 2024-08-16 DOI:10.1007/s40820-024-01481-7

Jiawang Hu, Hao Qian, Sanyang Han, Ping Zhang, Yuan Lu

引用次数: 0

Abstract

Highlights

Photoresponsive black phosphorus (BP)/Ti₃C₂T_x composites were synthesized by a self-assembly strategy.
Enhanced gas sensitive property was achieved by visible light modulation.
Light activated virtual sensor array was fabricated based on BP/Ti₃C₂T_x composite.
Diagnosis of coronary heart disease was achieved with the help of machine learning.

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利用机器学习的光激活虚拟传感器阵列用于冠心病的非侵入性诊断。

早期无创诊断冠心病（CHD）至关重要。然而，通过检测呼气来实现冠心病的准确诊断具有挑战性。在这项工作中，利用自组装策略配制了具有高气体灵敏度和光响应性的黑磷（BP）与二维碳化物和氮化物（MXene）的异质结构复合物。在光调节下制备了基于 BP/Ti3C2Tx 的光激活虚拟传感器阵列（LAVSA），并将其进一步组装成即时气体传感平台（IGSP）。此外，还引入了机器学习（ML）算法，帮助 IGSP 检测和识别呼气样本信号，以诊断心脏病。由于 BP 和 Ti3C2Tx 以及光激发的协同作用，合成的异质结构复合物比原始 Ti3C2Tx 表现出更高的性能，响应值比原始 Ti3C2Tx 高 26%。此外，在模式识别算法的帮助下，LAVSA 成功地检测和识别了 15 种气味分子，分别与醇、酮、醛、酯和酸有关。同时，在 ML 的帮助下，IGSP 对 45 名健康人和心脏病患者志愿者呼气气味的检测准确率达到了 69.2%。总之，我们设计并制造出了一种即时、低成本、准确的原型，用于无创诊断心脏病，为诊断其他疾病和其他更复杂的应用场景提供了通用解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

32.60

自引率

4.90%

发文量

981

审稿时长

1.1 months

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.