A portal to highly valuable indole-functionalized vinyl sulfonyl fluorides and allylic sulfonyl fluorides†

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-09-11 DOI:10.1039/d4ob01213e

Wenzhuo Huang , Eman Fayad , Ola A. Abu Ali , Hua-Li Qin

引用次数: 0

Abstract

A practical and efficient method for the C-3 site selective alkenylation of indoles was developed for constructing novel indole-functionalized vinyl sulfonyl fluorides and indolyl allylic sulfonyl fluorides. The reaction is accomplished with exclusive regio- and stereoselectivity without using transition metal catalysts, providing novel products of great potential value in medicinal chemistry, chemical biology, and drug discovery.

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通向高价值吲哚官能化乙烯磺酰氟和烯丙基磺酰氟的门户。

为构建新型吲哚官能化乙烯基磺酰氟和吲哚烯丙基磺酰氟，研究人员开发了一种 C-3 位点选择性烯化吲哚的实用高效方法。该反应在不使用过渡金属催化剂的情况下具有独特的区域和立体选择性，为药物化学、化学生物学和药物发现提供了极具潜在价值的新产品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.