Kigelia pinnata fruit extract mediated green synthesis of Ce11O20/CeCu/CuO nanocomposites and their anticancer and antibacterial properties

Abstract

In the current study, we used green synthesis techniques to conjugate additional metals into native nanoparticles, with an emphasis on how this altered its surface morphology and biological capabilities. It is an important turning point in the field of nanotechnology since it opens up new, dependable, environmentally friendly and manageable ways to prepare nanocomposites. This work employs a green synthetic technique to synthesize CuO nanparticles (KpCuO NPs), Ce₁₁O₂₀/CeCu/CuO nanocomposites (KpCe@CuO-5 and KpCe@CuO-10 NCs) using aqueous extract of Kigelia pinnata fruit. The materials were characterized by Fourier-Transform Infrared Spectroscopy (FTIR), surface area and porosity of nanocomposites analyzed with the Scanning Electronic Microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), UV-visible spectroscopy (UV–visible), X-ray Powder Diffraction (XDR), XPS (X-ray photoelectron spectroscopy), and High-Resolution Transmission Electron Microscopy (HRTEM). The synthesized KpCuO NPs, KpCe@CuO-5 and KpCe@CuO-10 nanocomposites exhibited anticancerous activity against MDA-MB-231, HEK-293 and antimicrobial properties against E. Coli bacteria. These samples also demonstrated their bio-potency by preventing the migration and proliferation of cells, decreasing the number of colonies, and triggering cell cycle arrest and programmed cell death. All of these findings suggest that KpCuO NPs and KpCe@CuO NCs have therapeutic potential to treat triple negative breast cancer (TNBC).