Advances in smart biomaterials that modulate the bone microenvironment to promote bone defect repair in diabetes mellitus

Q1 Engineering
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Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder that can affect the balance of bone metabolism and bone microenvironment, leading to impaired fracture healing. There are several underlying mechanisms which contributing to the impaired diabetic bone microenvironment such as hyperglycemia, the production of advanced glycation end products (AGEs), inflammation, and oxidative stress, etc. Recent studies have achieved great progress in developing novel smart biomaterials in improving the diabetic bone microenvironment to promote diabetic fracture healing. In this paper, we reviewed the mechanisms on DM-induced impaired fracture healing. Meanwhile, we also summarized the smart biomaterials used to improve the local microenvironment of diabetic fractures healing, which provides a novel perspective for the future treatment of fractures in diabetic patients.

Abstract Image

调节骨微环境以促进糖尿病患者骨缺损修复的智能生物材料的研究进展
糖尿病(DM)是一种慢性代谢性疾病,可影响骨代谢和骨微环境的平衡,导致骨折愈合受损。导致糖尿病骨微环境受损的潜在机制有多种,如高血糖、高级糖化终产物(AGEs)的产生、炎症和氧化应激等。最近的研究在开发新型智能生物材料改善糖尿病骨微环境以促进糖尿病骨折愈合方面取得了重大进展。本文综述了 DM 诱导骨折愈合受损的机制。同时,我们还总结了用于改善糖尿病骨折愈合局部微环境的智能生物材料,为未来糖尿病患者骨折的治疗提供了新的视角。
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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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